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PLA0002

Rabbit anti-Phospho BRCA1 (S1524) Antibody, Affinity Purified

Name: Rabbit anti-Phospho BRCA1 (S1524) Antibody, Affinity Purified
Brand: SIGMA

别名:

Fanconi anemia, BRCA1/BRCA2-containing complex, BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RING finger protein 53, RNF53, breast and ovarian cancer susceptibility protein 1, breast and ovarian cancer sususceptibility protein 1, breast cancer 1, complementation group S, early onset, early onset breast cancer 1, protein phosphatase 1, regulatory subunit 53, subunit 1, truncated BRCA1, truncated breast and ovarian cancer susceptibility protein 1, truncated breast and ovarian cancer sususceptibility protein 1, truncated breast cancer type 1 susceptibility protein

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关于此项目

NACRES:

NA.41

UNSPSC Code:

12352203

Species reactivity:

human

Technique(s):

proximity ligation assay: 1:1,000-1:10,000, western blot: 1:500- 1:5,000

Application:

PLA, WB

Citations:

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属性

biological source

rabbit

Quality Segment

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

species reactivity

human

technique(s)

proximity ligation assay: 1:1,000-1:10,000, western blot: 1:500- 1:5,000

accession no.

NP_009225.1

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

phosphorylation (pSer1524)

Gene Information

human ... BRCA1(672)

说明

Immunogen

Immunogen for PLA0002 was a phosphorylated synthetic peptide, which represented a portion of human Breast Cancer Gene 1 (GeneID 672) around serine 1524 according to the numbering given in entry NP_009225.1.

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Other Notes

BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c