PLA0095
Rabbit anti-SRC3 Antibody, Affinity Purified
Powered by Bethyl Laboratories, Inc.
别名:
ACTR, AIB-1, AIB1, CAGH16, CBP-interacting protein, CTG26, KAT13B, NCoA-3, RAC-3, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, amplified in breast cancer 1 protein, bHLHe42, class E basic helix-loop-helix protein 42, p/CIP, pCIP, receptor-associated coactivator 3, steroid receptor coactivator protein 3, thyroid hormone receptor activator molecule 1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Species reactivity:
human
Technique(s):
immunoprecipitation (IP): 2-10 μg/mg, western blot: 1:2,000-1:10,000
Application:
IP, WB
Citations:
2
biological source
rabbit
Quality Segment
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
species reactivity
human
technique(s)
immunoprecipitation (IP): 2-10 μg/mg, western blot: 1:2,000-1:10,000
accession no.
NP_858045.1
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... SRC3(8202)
General description
Steroid receptor coactivator-3 (SRC-3) is a transcriptional coactivator,. It belongs to the p160 SRC family. SRC-3 is located on human chromosome 20q13.
Immunogen
The epitope recognized by PLA0095 maps to a region between residue 900 and 950 of human Steroid Receptor Coactivator 3 using the numbering given in entry NP_858045.1 (GeneID 8202).
Biochem/physiol Actions
Steroid receptor coactivator-3 (SRC-3) participates in the genesis and development of various cancers. SRC-3 possesses histone acetyltransferase activity. It modulates the expression of target genes, that participates in various biological processes, such as cell proliferation, differentiation and migration. SRC-3 increases the migration and invasion of esophageal squamous cell carcinoma (ESCC) cells.
Physical form
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide
Other Notes
Steroid receptor coactivator 3 (SRC3) belongs to the SRC family of proteins that interacts with nuclear receptors to facilitate transcription. The 3 homologous members of this family are SRC-1 (NCoA-1), SRC-2 (GRIP1, TIF2, or NcoA-2), and SRC-3 (p/CIP, RAC3, ACTR, AIB1, or TRAM-1). SRC3 is an oncogene that is reported to be amplified and/or overexpressed in breast and gastric cancer and stimulates AKT signaling and cell growth and tumorigenesis.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable