Rabbit anti-ESCO2 Antibody, Affinity Purified

The epitope recognized by PLA0207 maps to a region between residue 200 and 250 of human establishment of cohesion 1 homolog 2 using the numbering given in entry NP_001017420.1 (GeneID 157570).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

ESCO2 (establishment of cohesion 1 homolog2) is an acetyltransferase that is essential to sister chromatid cohesion during S phase. Recent studies reveal that ESCO2 associates with components of the CoREST transcriptional repression complex. ESCO2 has also been shown to possess histone H3 K9 methylation activity. These findings suggest a role for ESCO2 in transcriptional regulation via the modulation of chromatin structure.

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