Rabbit anti-IKK-beta Antibody, Affinity Purified

The epitope recognized by PLA0218 maps to a region between residue 706 and 756 of human inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta using the numbering given in entry NP_001547.1 (GeneID 3551).

Tris-buffered Saline containing 0.1% BSA containing 0.09% Sodium Azide

IKK-beta (Inhibitor of nuclear factor kappa B kinase subunit beta) is one of three subunits that comprise the IKK complex. The IKK complex consists of two catalytic subunits, IKK-alpha and IKK-beta, and a regulatory subunit IKK-gamma/NEMO. As a kinase, IKK functions to phosphorylate members of the NF-kappa B inhibitor proteins, the I-kappa B proteins. Phosphorylation of I-kappa B proteins results in the ubiquitination and degradation of I kappa B and the release and translocation of the NF-kappa B transcription factor to the nucleus where it may function to activate a vast number of genes.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.