Rabbit anti-FANCE Antibody, Affinity Purified

The epitope recognized by PLA0240 maps to a region between residue 200 and 250 of human Fanconi anemia, complementation group E using the numbering given in entry NP_068741.1 (GeneID 2178).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

FANCE (Fanconi anemia, complementation group E) is a protein involved in DNA repair. Defects in FANCE are the cause of Fanconi anemia, a heterogenous autosomal recessive disorder characterized by congenital malformations and a predisposition to cancer. The FANCE gene is one of 13 complementation groups that include FANCA, FANCB, FANCC, FANCD1/BRCA2, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ/BRIP1, FANCL, FANCM, and FANCN/PALB2. FANCE has been shown to mediate the interaction between FANCC and FANCD2.

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