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Merck
CN

PLA0259

Rabbit anti-RuvBL2 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

别名:

48 kDa TATA box-binding protein-interacting protein, 48 kDa TBP-interacting protein, 51 kDa erythrocyte cytosolic protein, 51-KD, CGI-46, ECP-51, ECP51, INO80 complex subunit J, INO80J, RVB2, Reptin 52, Reptin52, RuvB (E coli homolog)-like 2, RuvB-like 2 (E. coli), TAP54-beta, TIH2, TIP48, TIP49b, TIP60-associated protein 54-beta, erythrocyte cytosolic protein, repressing pontin 52, reptin, reptin52 protein

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NACRES:
NA.41
UNSPSC Code:
12352203

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产品名称

Rabbit anti-RuvBL2 Antibody, Affinity Purified, Powered by Bethyl Laboratories, Inc.

biological source

rabbit

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

technique(s)

immunohistochemistry: 1:500- 1:2,000
immunoprecipitation (IP): 5-15 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_006657.1

UniProt accession no.

Q9Y230

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

rabbit ... RuvBL2(10856)

Biochem/physiol Actions

RuvB-like 2 (RUVBL2) plays a regulatory role in the Fanconia anemia (FA) pathway, the assembly of the telomerase holoenzyme, and nonsense-mediated mRNA decay (NMD). It may play a role in tumorigenesis and cancer progression. Overexpression of the RUVBL2 protein is observed in hepatocellular carcinoma (HCC), renal cell carcinoma, colorectal cancer, gastric cancer, breast cancer, and salivary gland cancer. It can be used as a promising target for preventing and treating HCC.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

RuvB-like 2 (RUVBL2), a transcription factor, belongs to the AAA+ protein subfamily of conserved ATPases linked with diverse cellular functions. A distinctive domain II (DII) protrudes from one side of the hexamer and defines two separate faces of the ring in RUVBL2.

Immunogen

The epitope recognized by PLA0259 maps to a region between residue 1 and 50 of human RuvB-like 2 using the numbering given in entry NP_006657.1 (GeneID 10856).

Other Notes

RuvB-like 2 (RuvBL2) is the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this protein has both ATPase and DNA helicase activities [taken from NCBI Entrez Gene (GeneID: 9400)].

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

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存储类别

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Multilevel regulation of RUVBL2 expression predicts poor prognosis in hepatocellular carcinoma.
Yan, et al.
Cancer Cell International, 19, 249-249 (2020)
Andres López-Perrote et al.
eLife, 9 (2020-11-19)
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that degrades aberrant mRNAs and also regulates the expression of a wide range of physiological transcripts. RUVBL1 and RUVBL2 AAA-ATPases form an hetero-hexameric ring that is part of several macromolecular complexes such

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