Rabbit anti-EPC1 Antibody, Affinity Purified

The epitope recognized by PLA0275 maps to a region between residue 325 and 375 of human Enhancer of Polycomb 1 using the numbering given in entry NP_079485.1 (GeneID 80314).

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Enhancer of polycomb homolog 1 (EPC1) is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H2F5 ]

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