PRS3627
Anti-LAMP-2 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Lysosomal-associated membrane protein 2
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunocytochemistry
indirect ELISA
western blot
indirect ELISA
western blot
Species reactivity:
mouse, human
Citations:
13
Technique(s):
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable
indirect ELISA: suitable
western blot: suitable
Uniprot accession no.:
产品名称
Anti-LAMP-2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human
technique(s)
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Lamp2(16784)
Application
Anti-LAMP-2 antibody has been used in immunofluorescence and western blot.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Immunofluorescence (1 paper)
Biochem/physiol Actions
LAMP2 (lysosome-associated membrane protein gene) preserves lysosomal membranes from acid proteolysis. It serves as an acidity biomarker in spheroids and xenografts. It also has some role in maturation of autophagic vacuoles and cell-cell or cell-extracellular matrix adhesion. Reduction of LAMP2 (lysosome-associated membrane protein gene) can increase acidosis-mediated toxicity. Mutation in LAMP2 can cause cardiomyopathy in young patients.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Lamp2 (lysosome-associated membrane protein gene)is located in the lysosomal lumen and lysosomal membrane. However upon chronic acidosis in the tumour microenvironment, it is found to be present in the plasma membrane.
Immunogen
a 17 amino acid peptide from near the center of human LAMP-2.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP3627.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells
Boothe T, et al.
Molecular Metabolism, 5(5), 366-378 (2016)
Tobias Boothe et al.
Molecular metabolism, 5(5), 366-378 (2016-04-26)
The role and mechanisms of insulin receptor internalization remain incompletely understood. Previous trafficking studies of insulin receptors involved fluorescent protein tagging at their termini, manipulations that may be expected to result in dysfunctional receptors. Our objective was to determine the
Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane
Damaghi M, et al.
Nature Communications, 6:8752 (2015)
Effects of white light-emitting diode (LED) exposure on retinal pigment epithelium in vivo
Jaadane I, et al.
Journal of Cellular and Molecular Medicine (2017)
Unique properties of lamp2a compared to other lamp2 isoforms
Cuervo AM and Dice JF
Journal of Cell Science, 113 Pt 24, 4441-4450 (2000)
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