PRS3985
Anti-Nicastrin (ab2) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-APH-2, Anti-Anterior pharynx defective 2, Anti-Nicastrin
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human, rat, mouse
技术
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NCSTN(23385)
一般描述
Nicastrin (NCSTN) is a transmembrane glycoprotein, that is located on chromosome 1q23.
免疫原
a 18 amino acid peptide from near the center of human Nicastrin.
应用
Anti-Nicastrin has been used in western blotting.
生化/生理作用
Nicastrin (NCSTN) helps in the assembly of γ-secretase complex. It is associated with Alzheimer′s disease.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide
其他说明
The action of this antibody can be blocked using blocking peptide SBP3985.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample
Dermaut B, et al.
American Journal of Human Genetics, 70(6), 1568-1574 (2002)
Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
Kuzuya A, et al.
BMC Biology, 14:25 (2016)
Akira Kuzuya et al.
BMC biology, 14, 25-25 (2016-04-03)
Synaptic loss strongly correlates with memory deterioration. Local accumulation of amyloid β (Aβ) peptide, and neurotoxic Aβ42 in particular, due to abnormal neuronal activity may underlie synaptic dysfunction, neurodegeneration, and memory impairments. To gain an insight into molecular events underlying
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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