PRS4003
Anti-APH1 (ab2) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Anterior pharynx defective 1 homolog A (C. elegans), Anti-Presenilin stabilization factor
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
predicted mol wt 29 kDa
种属反应性
mouse, human, rat
技术
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... APH1A(51107)
一般描述
APH1 (anterior pharynx defective-1) is a component of γ-secretase complex. It is located on chromosome 1q21. It has 2 unique isoforms such as APH1a, located on chromosome 1 and APH1b, located on chromosome 15 (3).
免疫原
a 18 amino acid peptide from near the center of human APH1.
生化/生理作用
APH1 (anterior pharynx defective-1) participates in the secretase like activity. Throughout the embryonic development, APH1 participates in presenilin dependent function.
外形
Solution in phosphate buffered saline containing 0.02% sodium azide
其他说明
The action of this antibody can be blocked using blocking peptide SBP4003.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes
Pardossi-Piquard R, et al.
The Journal of Biological Chemistry, 284(24), 16298-16307 (2009)
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin
Zhao G, et al.
The Journal of Neuroscience, 30(5), 1648-1656 (2010)
Exploiting protein-protein interaction networks for genome-wide disease-gene prioritization
Guney E and Oliva B
PLoS ONE, 7(9) (2012)
Elisa Canepa et al.
Alzheimer's & dementia : the journal of the Alzheimer's Association, 19(11), 5048-5073 (2023-05-15)
Cerebrovascular pathology is an early and causal hallmark of Alzheimer's disease (AD), in need of effective therapies. Based on the success of our previous in vitro studies, we tested for the first time in a model of AD and cerebral
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