PRS4553
Anti-Unc93b antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-Unc-93 homolog B1 (C. elegans), Anti-Unc93b1
产品名称
Anti-Unc93b antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, human, mouse
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... UNC93B1(81622)
Biochem/physiol Actions
Unc93b (unc-93 homolog B1) plays an important role in controlling the activation of TLRs (toll-like receptors). It also participates in the localization of TLR3 (toll-like receptor 3) to the surface of cell.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Unc93b (unc-93 homolog B1) is a multiple membrane-spanning protein, that is located in the endoplasmic reticulum. It is mainly present in the heart and also highly expressed in dendritic cells and macrophages. It is located on chromosome 11q13.
Immunogen
a 19 amino acid peptide from near the amino-terminus of human Unc93b.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP4553.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein
Kashuba VI, et al.
Gene, 283(1-2), 209-217 (2002)
Assessing the function of human UNC-93B in Toll-like receptor signaling and major histocompatibility complex II response
Koehn J, et al.
Human immunology, 68(11), 871-878 (2007)
Secretion of the human Toll-like receptor 3 ectodomain is affected by single nucleotide polymorphisms and regulated by Unc93b1
Qi R, et al.
The Journal of Biological Chemistry, 285(47), 36635-36644 (2010)
The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists
Pohar J, et al.
The Journal of Biological Chemistry, 288(1), 442-454 (2013)
Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing
Fukui R, et al.
The Journal of Experimental Medicine, 206(6), 1339-1350 (2009)
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