PRS4809
Anti-S1P1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-ECGF1, Anti-EDG1, Anti-S1PR1, Anti-Sphingosine-1-phosphate receptor 1
产品名称
Anti-S1P1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 42 kDa
species reactivity
human, mouse, rat
technique(s)
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... S1PR1(1901)
Biochem/physiol Actions
S1P1 (sphingosine-1-phosphate receptor 1) acts as an anti-apoptotic/pro-proliferative protein in AML (acute myeloid leukemia) cells. It participates in angiogenesis and lymphangiogenesis. It is considered as a pro-tumorigenic receptor, as it induces migration of cancer cell and invasion along with tumor neovascularization.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
S1P1 (sphingosine-1-phosphate receptor 1) is one of the transmembrane G protein coupled receptor. It is a member of the endothelial differentiation gene (EDG) family of receptors, hence it is also known as endothelial differentiation gene (EDG-1). It is located on chromosome 1p21.
Immunogen
a 14 amino acid peptide near the carboxy-terminus of the human S1P1.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP4809.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Sphingosine-1-phosph ate receptor 2
Adada M,et al.
FEBS Journal (2013)
S1PR1 mediates anti?apoptotic/pro?proliferative processes in human acute myeloid leukemia cells
Xu XQ, et al.
Molecular Medicine Reports, 14(4), 3369-3375 (2016)
Babita Rahar et al.
High altitude medicine & biology, 20(1), 78-88 (2019-03-21)
High altitude exposure alters biochemical, metabolic, and physiological features of heart and skeletal muscles, and hence has pathological consequences in these tissues. Central to these hypoxia-associated biochemical/metabolic shuffling are energy deficit accumulation of free radicals and ensuing oxidative damage in
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