PRS4887
抗-IL-17 (ab2) 兔抗
affinity isolated antibody, buffered aqueous solution
别名:
抗-CTLA8, 抗-白细胞介素17A
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
7
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human, mouse
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... IL17A(3605)
General description
IL-17A（白介素17a）是Th17（辅助T细胞）的促炎细胞因子。它定位于染色体6p12。
Immunogen
来自人IL-17A中心附近的19个氨基酸肽。
Biochem/physiol Actions
IL-17A（白介素17A）在自身免疫性疾病（如多发性硬化症和类风湿关节炎）的发病机理中起主要作用。它在过敏性鼻炎（AR）中也起着致病作用。它有助于气道上皮细胞中几种趋化因子和细胞因子的形成。
Physical form
溶剂为含有0.02％叠氮化钠的磷酸盐缓冲盐水
Other Notes
可以使用阻断肽SBP4887阻断该抗体的作用。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
IL-17A and Th17 cells in lung inflammation: an update on the role of Th17 cell differentiation and IL-17R signaling in host defense against infection
Tsai HC, et al.
Clinical & Developmental Immunology (2013)
Satsuki Shimizu et al.
Scientific reports, 13(1), 5041-5041 (2023-03-29)
Infantile skin problems not only cause temporary pain and discomfort, but also have a long-term impact on health. Hence, the purpose of this cross-sectional study was to clarify the relationship between inflammatory cytokines and Malassezia fungal facial skin problems in
Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat
Ichiyama K, et al.
The Journal of Biological Chemistry, 283(25), 17003-17008 (2008)
Timothy J Break et al.
Science (New York, N.Y.), 371(6526) (2021-01-16)
Human monogenic disorders have revealed the critical contribution of type 17 responses in mucosal fungal surveillance. We unexpectedly found that in certain settings, enhanced type 1 immunity rather than defective type 17 responses can promote mucosal fungal infection susceptibility. Notably
Association between polymorphisms in cytokine genes IL-17A and IL-17F and development of allergic rhinitis and comorbid asthma in Chinese subjects
Wang M, et al.
Human immunology, 73(6), 647-653 (2012)
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