PZ0004
伐尼克兰 酒石酸酯
≥98% (HPLC), α4β2 nAChR partial agonist, powder
别名:
7,8,9,10-四氢-6,10-亚甲基-6H-吡嗪并[2,3-h][3]苯并氮杂卓 酒石酸酯, 酒石酸伐仑克林
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关于此项目
经验公式（希尔记法）:
C13H13N3 · C4H6O6
化学文摘社编号:
分子量:
361.35
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
伐尼克兰 酒石酸酯, ≥98% (HPLC)
SMILES string
O[C@H]([C@@H](O)C(O)=O)C(O)=O.C1NC[C@H]2C[C@@H]1c3cc4nccnc4cc23
InChI key
TWYFGYXQSYOKLK-CYUSMAIQSA-N
InChI
1S/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1;5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2;1-2,5-6H,(H,7,8)(H,9,10)/t8-,9+;1-,2-/m.1/s1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: >5 mg/mL
storage temp.
room temp
Quality Level
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Application
酒石酸伐伦克林已被用于研究其在预脉冲抑制（PPI）下对大鼠感觉运动门控的作用。 它适合用作参考标准品，通过毛细管等速电泳（ITP）和毛细管区带电泳（CZE）在线耦合对尿液样本中的伐伦克林代谢产物进行定量。 它也适用于测试其对大鼠运动和非运动行为缺陷的作用。
Biochem/physiol Actions
酒石酸伐伦克林是一种部分α4β2烟碱样受体激动剂和α7完全激动剂。
酒石酸伐伦克林是一种部分α4β2烟碱样受体激动剂和α7完全激动剂。伐伦克林可竞争性地与α4β2受体结合，并在不产生完全尼古丁效应的情况下进行部分刺激，同时阻断尼古丁与受体结合的能力。因此，伐伦克林可阻断尼古丁激活α4β2受体并刺激中枢中脑边缘多巴胺系统的能力，这被认为是吸烟后增强和获得奖赏的神经元机制。
Features and Benefits
该化合物在受体分类和信号转导手册的乙酰胆碱受体（烟碱型）页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
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There is recognition that cognitive problems can contribute to renewed drug taking in former addicts. Our previous work has indicated that current smokers show reduced performance on a probabilistic reversal learning (PRL) task, relative to former smokers. To further explore
On-line column coupled isotachophoresis-capillary zone electrophoresis hyphenated with tandem mass spectrometry in drug analysis: Varenicline and its metabolite in human urine
Pievstansky J, et al.
Analytica Chimica Acta, 826, 84-93 (2014)
Toshiki Kurosawa et al.
Journal of pharmaceutical sciences, 106(9), 2576-2582 (2017-04-30)
Varenicline is a selective partial α
Yi-Hsuan Chuang et al.
Cancers, 12(5) (2020-05-28)
Although many studies have shown the association between smoking and the increased incidence and adverse prognosis of head and neck squamous cell carcinoma (HNSCC), the mechanisms and pharmaceutical targets involved remain unclear. Here, we integrated gene expression signatures, genetic alterations
Andrea de Bejczy et al.
Alcoholism, clinical and experimental research, 39(11), 2189-2199 (2015-09-29)
Alcohol dependence is a devastating illness affecting a large population, and new pharmacological treatments with good efficacy are greatly needed. One potential candidate is varenicline, a smoking cessation agent with partial agonist action at α4 β2 nicotinic acetylcholine receptors. A
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