主要文件

查看所有文档

PZ0005

伏立康唑

Name: 伏立康唑
Brand: SIGMA

≥98% (HPLC), powder, ergosterol synthesis inhibitor

别名:

2R，3S-2-（2,4-二氟苯基）-3-（5-氟嘧啶-4-基）-1-（1H-1,2,4-三唑-1-基）丁-2-醇, UK-109496

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₁₆H₁₄F₃N₅O

化学文摘社编号:

137234-62-9

分子量:

349.31

UNSPSC Code:

12352200

PubChem Substance ID:

329823674

NACRES:

NA.77

MDL number:

MFCD00905717

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

产品名称

伏立康唑, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: >20 mg/mL

storage temp.

room temp

SMILES string

C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F

InChI

1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1

InChI key

BCEHBSKCWLPMDN-MGPLVRAMSA-N

说明

General description

Voriconazole is a triazole and a synthetic derivative of fluconazole.

Application

Voriconazole has been used:

as a control and Erg11 inhibitor in YPD medium
as a reference drug to test the activity of essential oils against clinical strains of Candida sp.
as an antifungal agent to test its interactions with valproic acid (VPA)
to compare its in vitro antifungal activity with essential oils and its components against Cryptococcus neoformans azole-susceptible and not-susceptible clinical isolates

Biochem/physiol Actions

Voriconazole is used to treat invasive aspergillosis (IA). It is vigorous against Candida species, including the strains of Candida albicans, which shows resistance to fluconazole.

伏立康唑是用于治疗严重真菌感染的抗真菌药。伏立康唑通过抑制 CYP450 依赖性 14-α甾醇脱甲基酶来抑制麦角固醇合成，从而导致真菌细胞膜中的麦角固醇减少。

伏立康唑是一种抗真菌药，可抑制麦角固醇的合成。

Still not finding the right product?

Explore all of our products under 伏立康唑

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H341,H351,H361,H371,H372,H373,H412

pcodes

P202 - P260 - P264 - P273 - P280 - P301 + P310

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - STOT RE 1 - STOT RE 2 Oral - STOT SE 2 Oral

target_organs

Eyes, Liver,Kidney

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000216962

0000210740

030M4705V

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

商品

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Voriconazole: a new triazole antifungal agent

Saravolatz L D, et al.

Clinical Infectious Diseases, 36(5), 630-637 (2003)

Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents

Richie D L, et al.

Antimicrobial agents and chemotherapy, 57(5), 2272-2280 (2013)

pH-dependant antifungal activity of valproic acid against the human fungal pathogen Candida albicans

Chaillot J, et al.

Frontiers in Microbiology, 8, 1956-1956 (2017)

查看所有相关文献

全球贸易项目编号

货号	GTIN
PZ0005-5MG	04061836687250
PZ0005-25MG	04061836687243