Name: Sunitinib malate
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₂₂H₂₇FN₄O₂ · C₄H₆O₅

CAS Number:

341031-54-7

分子量:

532.56

MDL编号:

MFCD08282795

UNSPSC代码:

12352200

PubChem化学物质编号:

329823681

NACRES:

NA.77

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Product Name

Sunitinib malate, ≥98% (HPLC)

方案

≥98% (HPLC)

表单

powder

溶解性

DMSO: >10 mg/mL

储存温度

room temp

SMILES字符串

O[C@@H](CC(O)=O)C(O)=O.CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C

InChI

1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;/t;2-/m.0/s1

InChI key

LBWFXVZLPYTWQI-IPOVEDGCSA-N

基因信息

human ... CSF1R(1436), FLT1(2321), FLT3(2322), FLT4(2324), KDR(3791), KIT(3815), PDGFRA(5156), PDGFRB(5159), RET(5979)

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应用

Sunitinib malate has been used:

to study its mechanism in the inhibition of MCF-7 cell migration and angiogenesis
as a reference molecule to compare its docking energies with other ligands/vascular endothelial growth factor receptor (VEGF) receptor blocker
used in proliferation assay

生化/生理作用

Sunitinib has greater bioavailability and potency compared to other inhibitors. It prevents angiogenesis.

Sunitinib malate is a receptor tyrosine kinase inhibitor, which targets VEGF-R1, VEGF-R2, VEGF-R3, PDGF-Rα, PDGF-Rβ, KIT, FLT3, CSF-1R, and RET. Sunitinib malate is an anticancer drug.

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.