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Merck
CN

PZ0015

Trovafloxacin mesylate

>98% (HPLC), powder, Pannexin 1 inhibitor

别名:

(1α,5α,6α)-7-(6-Amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid methanesulfonate, CP-99219-27, Trovafloxacin methanesulfonate

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关于此项目

经验公式（希尔记法）:
C20H15F3N4O3 · CH3SO3H
化学文摘社编号:
147059-75-4
分子量:
512.46
MDL编号:
MFCD00913361
UNSPSC代码:
12352200
PubChem化学物质编号:
329823684
NACRES:
NA.77

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产品名称

Trovafloxacin mesylate, >98% (HPLC)

质量水平

100

方案

>98% (HPLC)

表单

powder

颜色

white to off-white

溶解性

DMSO: >10 mg/mL

储存温度

room temp

SMILES字符串

CS(O)(=O)=O.NC1C2CN(CC12)c3nc4N(C=C(C(O)=O)C(=O)c4cc3F)c5ccc(F)cc5F

InChI

1S/C20H15F3N4O3.CH4O3S/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24;1-5(2,3)4/h1-4,7,10-11,16H,5-6,24H2,(H,29,30);1H3,(H,2,3,4)/t10-,11+,16+;

InChI key

DYNZICQDCVYXFW-AHZSKCOESA-N

应用

Trovafloxacin mesylate has been used as a test compound in toxicity assay to assess its toxicity in 2D hepatocyte cultures. It has also been used to manipulate the mechanism of apoptotic cell disassembly during apoptosis.

生化/生理作用

Trovafloxacin mesylate acts as a pannexin1 (Panx1) inhibitor.
Trovafloxacin mesylate is a broad spectrum antibiotic.
Trovafloxacin mesylate is a broad spectrum antibiotic. Trovafloxacin mesylate blocks the activity of DNA gyrase and topoisomerase IV, enzymes essential in the repliction, transcription, and repair of bacterial DNA.

象形图

Health hazardCorrosion
GHS08,GHS05

警示用语：

Danger

危险声明

H314,H361

危险分类

Repr. 2 - Skin Corr. 1B

储存分类代码

8A - Combustible corrosive hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
020M4708V
020M47081
020M4708

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Bioprinted 3D primary liver tissues allow assessment of organ-level response to clinical drug induced toxicity in vitro
Nguyen DG, et al.
PLoS ONE, 11(7), e0158674-e0158674 (2016)
Determining the contents and cell origins of apoptotic bodies by flow cytometry
Jiang L, et al.
Scientific reports, 7(1), 14444-14444 (2017)
Akira Nakajima et al.
Cell biology and toxicology, 34(1), 65-77 (2017-03-13)
Fluoroquinolones and propionic acid derivatives are widely used antibacterials and non-steroidal anti-inflammatory drugs, respectively, which have been reported to frequently trigger drug hypersensitivity reactions. Such reactions are induced by inflammatory mediators such as cytokines and chemokines. The present study investigated
Jieyu Xu et al.
Toxicology in vitro : an international journal published in association with BIBRA, 48, 286-301 (2018-02-07)
Immortalized liver cells have been used for evaluating the toxicity of compounds; however, excessive glutathione is considered to lessen cytotoxicity. In this study, we compared the effects of glutathione depletion on cytotoxicities of drugs using HepaRG and HepG2 cells, which

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Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

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