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Merck
CN

PZ0021

Tigecycline hydrate

≥98% (HPLC), bacterial protein synthesis inhibitor, powder

别名:

9-t-Butylglycylamido-minocycline hydrate, TBG-MINO, Tigecyclin, Tygacil

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关于此项目

经验公式（希尔记法）:
C29H39N5O8 · xH2O
化学文摘社编号:
1229002-07-6
分子量:
585.65 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329823688
NACRES:
NA.77

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产品名称

Tigecycline hydrate, ≥98% (HPLC)

SMILES string

O.CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(cc(NC(=O)CNC(C)(C)C)c(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)N(C)C

InChI

1S/C29H39N5O8.H2O/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36;/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35);1H2/t12-,14-,21-,29-;/m0./s1

InChI key

PMPLAEFBZIFHAR-KXLOKULZSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -175 to -205°, c = 0.15 in methanol

color

off-white to yellow-brown

solubility

DMSO: ≥3 mg/mL (warmed)

storage temp.

2-8°C

Quality Level

100

相关类别

General description

Tigecycline is used to treat complicated skin and skin structure infections (cSSSI) and complicated intraabdominal infections.

Application

TIGECYCLINE HYDRATE has been used:
  • for antibiotic susceptibility testing
  • to study its effects on multiple nonsmall cell lung cancer (NSCLC) cell lines
  • to evaluate its effects on the binding of fluoroquinolones to human serum albumin
  • as a standard to investigate the penetration of tigecycline into cornea, aqueous humor and vitreous humor

Biochem/physiol Actions

Tigecycline is a broad spectrum glycylcycline antibiotic.
Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.

Other Notes

air sensitive

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Repr. 1B - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000321754
0000321754
0000269497
0000269500
0000269500

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访问文档库

Ocular penetration of topically applied 1% tigecycline in a rabbit model
Sakarya Y, et al.
International journal of ophthalmology, 10(5), 679-679 (2017)
In vitro activity of tigecycline against isolates from patients enrolled in phase 3 clinical trials of treatment for complicated skin and skin-structure infections and complicated intra-abdominal infections
Bradford PA, et al.
Clinical Infectious Diseases, 41 (2005)
Hubert Ziółkowski et al.
Poultry science, 99(10), 4750-4757 (2020-09-30)
Tetracyclines continue to be important antimicrobials in veterinary medicine. However, the pharmacokinetics (PK) of tigecycline (TIG) and minocycline (MIN) in broiler chickens has not been investigated to date, and the PK of chlortetracycline (CTC) and tetracycline (TET) remains insufficiently researched
The Effect of Tigecycline on the Binding of Fluoroquinolones to Human Serum Albumin
Jelic RM, et al.
Serbian Journal of Experimental and Clinical Research, 19(1), 17-25 (2018)
Tigecycline targets nonsmall cell lung cancer through inhibition of mitochondrial function
Jia X, et al.
Fundamental & Clinical Pharmacology, 30(4), 297-306 (2016)
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商品

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

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