PZ0036
甘草酸鲁卡帕里布
≥98% (HPLC)
别名:
8-氟-1,3,4,5-四氢-2- [4-[（（甲基氨基）甲基]苯基] -6H-吡咯并[4,3,2-ef] [2]苯并ze庚因-6-芳基磺酸盐
产品名称
甘草酸鲁卡帕里布, ≥98% (HPLC)
InChI
1S/C19H18FN3O.C10H16O4S/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15;1-9(2)7-3-4-10(9,8(11)5-7)6-15(12,13)14/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24);7H,3-6H2,1-2H3,(H,12,13,14)/t;7-,10-/m.1/s1
InChI key
INBJJAFXHQQSRW-STOWLHSFSA-N
SMILES string
FC1=CC(C(NCC2)=O)=C3C2=C(C4=CC=C(CNC)C=C4)NC3=C1.CC5(C)[C@@H]6CC[C@@]5(CS(O)(=O)=O)C(C6)=O
assay
≥98% (HPLC)
form
powder
color
pale yellow
solubility
DMSO: 2 mg/mL, clear
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
PARP 抑制剂；抗癌药
卢卡帕尼是 DNA 修复酶聚 ADP 核糖聚合酶-1（PARP-1）的抑制剂。研究发现，它在许多癌症中均具有抗癌活性，并已被批准用于治疗先前治疗过的 BRCA 突变型卵巢癌。
signalword
Warning
hcodes
Hazard Classifications
Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Yaroslava Karpova et al.
Biochemical pharmacology, 167, 149-162 (2019-03-19)
In our previous studies of the molecular mechanisms of poly(ADP-ribose) polymerase 1 (PARP-1)-mediated transcriptional regulation we identified a novel class of PARP-1 inhibitors targeting the histone-dependent route of PARP-1 activation. Because histone-dependent activation is unique to PARP-1, non-NAD-like PARP-1 inhibitors
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