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Merck
CN

PZ0113

Sigma-Aldrich

PD173952

≥98% (HPLC)

别名:

6-(2,6-Dichlorophenyl)-8-methyl-2-(4-morpholin-4-ylphenylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, PD-173952

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关于此项目

经验公式（希尔记法）:
C24H21Cl2N5O2
化学文摘社编号:
305820-75-1
分子量:
482.36
MDL编号:
MFCD16875428
UNSPSC代码:
12352200
PubChem化学物质编号:
329823705
NACRES:
NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

yellow to green

溶解性

DMSO: >10 mg/mL

储存温度

2-8°C

SMILES字符串

CN1C(=O)C(=Cc2cnc(Nc3ccc(cc3)N4CCOCC4)nc12)c5c(Cl)cccc5Cl

InChI

1S/C24H21Cl2N5O2/c1-30-22-15(13-18(23(30)32)21-19(25)3-2-4-20(21)26)14-27-24(29-22)28-16-5-7-17(8-6-16)31-9-11-33-12-10-31/h2-8,13-14H,9-12H2,1H3,(H,27,28,29)

InChI key

XZEJMVDCQZRHLN-UHFFFAOYSA-N

生化/生理作用

PD173952 is a Src family kinase inhibitor.

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

储存分类代码

11 - Combustible Solids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000383512
0000383512
010M4742V
010M4742

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Alexander Rohe et al.
Bioorganic & medicinal chemistry, 23(15), 4936-4942 (2015-06-11)
Myt1 kinase is a member of the Wee-kinase family involved in G2/M checkpoint regulation of the cell cycle. So far, no peptide substrate suitable for activity-based screening has been reported, hampering systematic development of Myt1 kinase inhibitors. Myt1 inhibitors had

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Src Family Kinases Overview

Src is the original member of a group of non-receptor protein-tyrosine kinases termed the Src family kinases (SFKs). Learn about the SFKs that, in humans, consist of eight members, a small group of atypical members, and two related kinases.

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

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