PZ0116
PD-166285 hydrate
≥98% (HPLC)
别名:
6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride hydrate
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关于此项目
经验公式（希尔记法）:
C26H27Cl2N5O2·2HCl
分子量:
585.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
InChI key
FHIIMEXCWLFXBU-UHFFFAOYSA-N
SMILES string
O.Cl.Cl.CCN(CC)CCOc1ccc(Nc2ncc3C=C(C(=O)N(C)c3n2)c4c(Cl)cccc4Cl)cc1
InChI
1S/C26H27Cl2N5O2.2ClH.H2O/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28;;;/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31);2*1H;1H2
assay
≥98% (HPLC)
form
powder
color
yellow
solubility
DMSO: ≥20 mg/mL, H2O: ≥5 mg/mL
storage temp.
room temp
Quality Level
Application
PD-166285 Hydrate has been used as a fibroblast growth factor (FGF) signaling inhibitor to study its effects on LIM-homeodomain gene 9 (Lhx9) expression during limb development in mice.
Biochem/physiol Actions
PD-166285 hydrate is a broad spectrum protein tyrosine kinase inhibitor; Src and FGFR kinase inhibitor.
PD-166285 is also a potent inhibitor of Wee-1, epidermal growth factor receptor, and platelet-derived growth factor receptor β subunit (PDGFR-β). It also exhibits its inhibitory effects against mitogen-activated protein kinase (MAPK) and protein kinase C (PKC). PD-166285 shows antiproliferative and anti-migratory effects due to which it may be used as a therapeutic agent against atherosclerosis, restenosis, and cancer.
Features and Benefits
This compound is featured on the FGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 4
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
R L Panek et al.
The Journal of pharmacology and experimental therapeutics, 283(3), 1433-1444 (1998-02-12)
PD 166285, a novel protein tyrosine kinase inhibitor of a new structural class, the 6-aryl-pyrido[2,3-d]pyrimidines, was synthesized as the most potent and soluble analog of a series of small molecules originally identified by screening a compound library with assays that
Suzanne Leijen et al.
Current clinical pharmacology, 5(3), 186-191 (2010-04-22)
Inducing DNA damage is a well known strategy for attacking cancer, already being used for many years by the application of a variety of anti cancer drugs. Tumor cells and other rapidly dividing cells are more sensitive to DNA damage
Yisheng Yang et al.
Gene expression patterns : GEP, 19(1-2), 45-51 (2015-07-30)
Lhx9 is a member of the LIM-homeodomain gene family necessary for the correct development of many organs including gonads, limbs, heart and the nervous system. In the context of limb development, Lhx9 has been implicated as an integrator for Fibroblast
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