PD-166285 hydrate

Name: PD-166285 hydrate
Brand: SIGMA

≥98% (HPLC)

别名:

6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride hydrate

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₂₆H₂₇Cl₂N₅O₂·2HCl

分子量:

585.35

MDL编号:

MFCD17215957

UNSPSC代码:

51111800

PubChem化学物质编号:

329823708

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

yellow

溶解性

DMSO: ≥20 mg/mL
H₂O: ≥5 mg/mL

储存温度

room temp

SMILES字符串

O.Cl.Cl.CCN(CC)CCOc1ccc(Nc2ncc3C=C(C(=O)N(C)c3n2)c4c(Cl)cccc4Cl)cc1

InChI

1S/C26H27Cl2N5O2.2ClH.H2O/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28;;;/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31);2*1H;1H2

InChI key

FHIIMEXCWLFXBU-UHFFFAOYSA-N

应用

PD-166285 Hydrate has been used as a fibroblast growth factor (FGF) signaling inhibitor to study its effects on LIM-homeodomain gene 9 (Lhx9) expression during limb development in mice.

生化/生理作用

PD-166285 hydrate is a broad spectrum protein tyrosine kinase inhibitor; Src and FGFR kinase inhibitor.

PD-166285 is also a potent inhibitor of Wee-1, epidermal growth factor receptor, and platelet-derived growth factor receptor β subunit (PDGFR-β). It also exhibits its inhibitory effects against mitogen-activated protein kinase (MAPK) and protein kinase C (PKC). PD-166285 shows antiproliferative and anti-migratory effects due to which it may be used as a therapeutic agent against atherosclerosis, restenosis, and cancer.

特点和优势

This compound is featured on the FGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.