PZ0124
CP-66713
≥98% (HPLC)
别名:
8-chloro-1-phenyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine, PF-1716311
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关于此项目
经验公式（希尔记法）:
C15H10ClN5
化学文摘社编号:
分子量:
295.73
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
产品名称
CP-66713, ≥98% (HPLC)
InChI
1S/C15H10ClN5/c16-10-6-7-11-12(8-10)21-14(9-4-2-1-3-5-9)19-20-15(21)13(17)18-11/h1-8H,(H2,17,18)
SMILES string
Nc1nc2ccc(Cl)cc2n3c(nnc13)-c4ccccc4
InChI key
PBENJWAFQLORQL-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: ≥5 mg/mL
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
CP-66713 is an adenosine A2 receptor antagonist.
Features and Benefits
This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Interaction between adenosine A1 and A2 receptor-mediated responses in the rat hippocampus in vitro.
E M O'Kane et al.
European journal of pharmacology, 362(1), 17-25 (1998-12-29)
Previous work has been carried out on the effects of adenosine on transmitter release and on the excitability of postsynaptic neurones, but little is known about the effects of adenosine on the coupling between the two. In this study, we
T Matsugi et al.
Investigative ophthalmology & visual science, 38(13), 2695-2701 (1998-01-07)
To investigate the effect of adenosine on the contractile tone of cultured bovine retinal pericytes. Changes in the contractile tone were quantified as the changes in the summed length of wrinkles induced by pericytes on the silicone surface on which
S Fujii et al.
Neuroscience letters, 148(1-2), 148-150 (1992-12-14)
The effects of the adenosine A2 receptor antagonist CP-66713 on the reversal of long-term potentiation (LTP) were studied in CA1 neurons of guinea pig hippocampal slices. Reduction of LTP (depotentiation, DP) was effected by delivering a train of low-frequency afferent
H Fuder et al.
Naunyn-Schmiedeberg's archives of pharmacology, 345(4), 417-423 (1992-04-01)
To investigate whether endogenous purinoceptor agonists affect the sympathetic neurotransmission in the rat isolated iris, and to classify the purinoceptors modulating exocytotic [3H]-noradrenaline release, we have determined the effect of adenosine receptor antagonists on, and the relative potency of selected
M Suzuki et al.
Japanese journal of pharmacology, 68(1), 119-123 (1995-05-01)
We examined the effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) and (R)-7,8-dihydro-8-ethyl-2-(3-noradamantyl)-4-propyl-1H-imidazo[2,1 -i]purin- 5(4H)-one (KF20274), selective adenosine A1-receptor antagonists, on the gastrointestinal propulsion in rats, as compared with those of the laxative bisacodyl. DPCPX and KF20274 (p.o.) dose-dependently increased the fecal pellet output
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