PZ0160
UK-5099
≥98% (HPLC), powder, mitochondrial pyruvate carrier inhibitor
别名:
2-氰基-3-(1-苯基-1H-吲哚-3-基)-2-丙烯酸, PF-1005023
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关于此项目
经验公式（希尔记法）:
C18H12N2O2
化学文摘社编号:
分子量:
288.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
UK-5099, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
yellow to tan
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
SMILES string
OC(=O)\C(=C\c1cn(-c2ccccc2)c3ccccc13)C#N
InChI
1S/C18H12N2O2/c19-11-13(18(21)22)10-14-12-20(15-6-2-1-3-7-15)17-9-5-4-8-16(14)17/h1-10,12H,(H,21,22)/b13-10+
InChI key
BIZNHCWFGNKBBZ-JLHYYAGUSA-N
Application
UK-5099已用于：
- 在用于前列腺癌细胞系培养的Roswell公园纪念研究所（RPMI）1640培养基中用作线粒体丙酮酸阻滞剂，以减少丙酮酸向线粒体的运输
- 二甲基亚砜（DMSO）的储备液中， 以研究抑制丙酮酸转运入线粒体对脂多糖激活的巨噬细胞促炎反应的影响
- 局部处理，以用于研究其对实验小鼠毛发周期诱导的作用
Biochem/physiol Actions
UK-5099可诱导产生乳酸。
UK-5099是线粒体丙酮酸转运蛋白的有效抑制剂。
UK-5099是线粒体丙酮酸转运蛋白的有效抑制剂。n大鼠心脏线粒体，UK-5099可抑制丙酮酸依赖性O2消耗，IC50 为50 nM。
Features and Benefits
该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。
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存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
M S Shearman et al.
The Biochemical journal, 223(3), 673-676 (1984-11-01)
alpha-Cyano-beta-(1-phenylindol-3-yl)acrylate inhibited pyruvate transport into both liver and heart mitochondria approximately linearly with respect to its concentration until 65% inhibition was achieved. The extent of inhibition was dependent on the mitochondrial protein concentration. By extrapolation of plots of inhibition versus
M O Proudlove et al.
The Biochemical journal, 247(2), 441-447 (1987-10-15)
1. Mitochondria isolated from the thermogenic spadices of Arum maculatum and Sauromatum guttatum plants oxidized external NADH, succinate, citrate, malate, 2-oxoglutarate and pyruvate without the need to add exogenous cofactors. 2. Oxidation of substrates was virtually all via the alternative
Ajit S Divakaruni et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(14), 5422-5427 (2013-03-21)
Facilitated pyruvate transport across the mitochondrial inner membrane is a critical step in carbohydrate, amino acid, and lipid metabolism. We report that clinically relevant concentrations of thiazolidinediones (TZDs), a widely used class of insulin sensitizers, acutely and specifically inhibit mitochondrial
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| PZ0160-5MG | 04061836687465 |
| PZ0160-25MG | 04061836687458 |