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安全信息

PZ0174

Sigma-Aldrich

Sonepiprazole hydrate

≥98% (HPLC)

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别名:
4-[4-[2-[(1S)-Isochroman-1-yl]ethyl]piperazin-1-yl]benzenesulfonamide hydrate, PNU-101387, PNU-101387G, U-101387
经验公式（希尔记法）:
C21H27N3O3S · xH2O
CAS号:
170858-33-0
分子量:
401.52 (anhydrous basis)
MDL编号:
MFCD05662325
PubChem化学物质编号:
329823748
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to off-white

溶解性

DMSO: >10 mg/mL

储存温度

room temp

SMILES string

NS(=O)(=O)c1ccc(cc1)N2CCN(CC[C@@H]3OCCc4ccccc34)CC2

InChI

1S/C21H27N3O3S/c22-28(25,26)19-7-5-18(6-8-19)24-14-12-23(13-15-24)11-9-21-20-4-2-1-3-17(20)10-16-27-21/h1-8,21H,9-16H2,(H2,22,25,26)/t21-/m0/s1

InChI key

WNUQCGWXPNGORO-NRFANRHFSA-N

生化/生理作用

Sonepiprazole (U-101387) is a selective D4 dopamine antagonist. Ki = 10 nM for the dopamine D4.2 receptor.

特点和优势

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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A F Arnsten et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 23(4), 405-410 (2000-09-16)
Stress exposure impairs the cognitive functioning of the prefrontal cortex (PFC). Previous research has examined the dopamine (DA) D1 receptor mechanisms underlying this response. The current study performed a preliminary examination of the role of D4 receptor mechanisms by determining
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.
R E TenBrink et al.
Journal of medicinal chemistry, 39(13), 2435-2437 (1996-06-21)
Peter Hertel et al.
European journal of pharmacology, 573(1-3), 148-160 (2007-08-11)
The present study describes the pharmacological profile of the putative antipsychotic drug Lu 35-138 ((+)-(S)-3-{1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-3,6-dihydro-2H-pyridin-4-yl}-6-chloro-1H-indole). The in vitro receptor profile of Lu 35-138 revealed high affinity (K(i)=5 nM) and competitive antagonism (K(b)=8 nM) at dopamine D(4) receptors combined with potent
R S Mansbach et al.
Psychopharmacology, 135(2), 194-200 (1998-03-13)
Recent evidence suggests that the dopamine D4 receptor may play a role in schizophrenia, and that the atypical properties of the antipsychotic clozapine may be attributable in part to its antagonistic actions at this receptor. In the present study, clozapine
K Noda-Saita et al.
Biochemical and biophysical research communications, 255(2), 367-370 (1999-03-02)
Dopamine D4-like binding sites are abundant in human cerebral cortex as detected by [3H]nemonapride. The extremely low density of D4 mRNA in human cerebral cortex is inconsistent with the high amount of D4-like binding sites. To investigate the nature of
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