PZ0177
OSU6162 hydrochloride
≥98% (HPLC)
别名:
PNU-96391; PNU-0096391; OSU-6162; (S)-(-)-(3-methanesulfonyl-phenyl)-1-propyl-piperidine hydrochloride; (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride
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关于此项目
经验公式（希尔记法）:
C15H23NO2S·HCl
化学文摘社编号:
分子量:
317.87
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
产品名称
OSU6162 hydrochloride, ≥98% (HPLC)
InChI
1S/C15H23NO2S.ClH/c1-3-9-16-10-5-7-14(12-16)13-6-4-8-15(11-13)19(2,17)18;/h4,6,8,11,14H,3,5,7,9-10,12H2,1-2H3;1H/t14-;/m1./s1
SMILES string
Cl.CCCN1CCC[C@H](C1)c2cccc(c2)S(C)(=O)=O
InChI key
LEMGVHZVBREXAD-PFEQFJNWSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -5 to -7°, c = 1 in methanol
color
white to tan
solubility
H2O: ≥16 mg/mL
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
OSU6162 (PNU-96391) is a dopamine stabilizer, a drug that can stimulate or inhibit dopaminergic signaling depending on the dopaminergic tone. Dopaminergic stabilizers have been proposed to act as partial dopamine receptor agonists or as antagonists with both dopamine and behavioral stabilizing activity. Although affinity is not high (in vitro binding affinity for dopamine D2 receptor has a Ki of 447 nM), OSU6162 shows a high level of receptor occupancy.
OSU6162 is a dopamine stabilizer
Features and Benefits
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Nelleke Tolboom et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(2), 472-479 (2014-09-25)
(-)-OSU6162 is a dopamine stabilizer that can counteract both hyperdopaminergic and hypodopaminergic states. In this study, D2/D3 receptor occupancy of (-)-OSU6162 in the human brain was investigated using positron emission tomography (PET). Twelve male healthy volunteers underwent [(11)C]raclopride PET scanning
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