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经验公式(希尔记法):
C22H28N6O3S · CH3SO3H
化学文摘社编号:
分子量:
552.67
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
InChI key
MEPNHSOMXMALDZ-UHFFFAOYSA-N
SMILES string
CS(O)(=O)=O.CC(C)Nc1cccnc1N2CCN(CC2)C(=O)c3cc4cc(NS(C)(=O)=O)ccc4[nH]3
InChI
1S/C22H28N6O3S.CH4O3S/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20;1-5(2,3)4/h4-8,13-15,24-26H,9-12H2,1-3H3;1H3,(H,2,3,4)
assay
≥98% (HPLC)
form
powder
color
white to tan
mp
315 °C
solubility
DMSO: >5 mg/mL
storage temp.
room temp
Quality Level
Biochem/physiol Actions
Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It is used as part of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) type 1.
Non-nucleoside reverse transcriptase inhibitor (NNRTI); Anti-retroviral.
Features and Benefits
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
I-Chan Huang et al.
Health services research, 43(1 Pt 1), 327-339 (2008-01-24)
To compare different approaches to address ceiling effects when predicting EQ-5D index scores from the 10 subscales of the MOS-HIV Health Survey. Data were collected from an HIV treatment trial. Statistical methods included ordinary least squares (OLS) regression, the censored
Zandrea Ambrose et al.
Journal of virology, 83(8), 3826-3833 (2009-02-06)
We previously identified a rare mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), I132M, which confers high-level resistance to the nonnucleoside RT inhibitors (NNRTIs) nevirapine and delavirdine. In this study, we have further characterized the role of
Matthis Geitmann et al.
Journal of medicinal chemistry, 49(8), 2367-2374 (2006-04-14)
Details of the interaction between HIV-1 reverse transcriptase and non-nucleoside inhibitors (NNRTIs) have been elucidated using a biosensor-based approach. This initial study was performed with HIV-1 reverse transcriptase mutant K103N, the phenethylthioazolylthiourea compound (PETT) MIV-150, and the three NNRTIs licensed
Philippe Selhorst et al.
Antimicrobial agents and chemotherapy, 55(4), 1403-1413 (2011-02-02)
Microbicides based on nonnucleoside reverse transcriptase inhibitors (NNRTIs) are currently being developed to protect women from HIV acquisition through sexual contact. However, the large-scale introduction of these products raises two major concerns. First, when these microbicides are used by undiagnosed
Hui Xu
Mini reviews in medicinal chemistry, 10(1), 62-72 (2010-04-13)
Since the first case of acquired immunodeficiency syndrome (AIDS) was reported in 1981, AIDS, as the global disease affecting 33.2 million people in 2007, has always been an unsolved problem worldwide. Reverse transcriptase (RT) is a crucial enzyme in the
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