Merck
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文件

PZ0181

Sigma-Aldrich

PD184352

≥98% (HPLC)

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别名:
2-（2-氯-4-碘代苯氨基）-N-环丙基甲氧基-3,4-二氟苯甲酰胺, CI-1040
经验公式（希尔记法）:
C17H14ClF2IN2O2
CAS号:
212631-79-3
分子量:
478.66
MDL编号:
MFCD02683961
PubChem化学物质编号:
329823755
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

颜色

white to tan

溶解性

DMSO: ≥30 mg/mL

储存温度

room temp

SMILES string

Fc1ccc(C(=O)NOCC2CC2)c(Nc3ccc(I)cc3Cl)c1F

InChI

1S/C17H14ClF2IN2O2/c18-12-7-10(21)3-6-14(12)22-16-11(4-5-13(19)15(16)20)17(24)23-25-8-9-1-2-9/h3-7,9,22H,1-2,8H2,(H,23,24)

InChI key

GFMMXOIFOQCCGU-UHFFFAOYSA-N

Gene Information

human ... MAP2K1(5604) , MAP2K2(5605)

生化/生理作用

PD184352（CI-1040）是 MEK（MKK1；MAPK 激酶）和密切相关的 MKK2 的高度选择性非竞争性抑制剂。它具有抗癌活性，抑制 ERK 通路，已与其他类型的抑制剂一起用于建立胚胎干细胞系。

特点和优势

《受体分类和信号转导》手册的 MAPK 页面有该化合物的介绍。如需浏览其他手册页面，请点击此处。

象形图

Environment
GHS09

警示用语：

Warning

危险声明

H400

预防措施声明

P273 - P391 - P501

危险分类

Aquatic Acute 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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