PZ0183
ERB-041
≥98% (HPLC)
别名:
2-（3-氟-4-羟基苯基）-7-乙烯基-1,3-苯并恶唑-5-醇, WAY-202041, 普林贝瑞
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C15H10FNO3
化学文摘社编号:
分子量:
271.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥25 mg/mL
storage temp.
room temp
SMILES string
OC(C=C1)=C(F)C=C1C2=NC3=CC(O)=CC(C=C)=C3O2
InChI
1S/C15H10FNO3/c1-2-8-5-10(18)7-12-14(8)20-15(17-12)9-3-4-13(19)11(16)6-9/h2-7,18-19H,1H2
InChI key
MQIMZDXIAHJKQP-UHFFFAOYSA-N
Gene Information
human ... ESR2(2100)
Biochem/physiol Actions
ERB-041 是一种强效、选择性 ERβ 受体激动剂（IC50 ERβ：5.4 nM；是 ERα 选择性的 200 倍以上）
ERB-041 是一种强效、选择性雌激素 ERβ 受体激动剂（IC50 ERβ：5.4 nM；选择性是 ERα 的 200 倍以上）。ERβ 在子宫、下丘脑/垂体、骨骼和其他经典雌激素靶组织中介导雌激素作用的作用较小。然而，目前已经确立 ERβ 在卵巢、心血管系统和脑以及炎症动物模型（包括关节炎、子宫内膜异位症、炎症性肠病和败血症）中的明确作用。人们对寻找 ERβ 激动剂越来越感兴趣，其可用于各种临床应用而不会引发经典的雌激素副作用。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
We offers many products related to Nuclear Receptors (Steroids) for your research needs.
我们可提供多种核受体（类固醇）相关产品，满足您的各类研究需求。
Sreenivasan Paruthiyil et al.
PloS one, 4(7), e6271-e6271 (2009-07-18)
Estrogens produce biological effects by interacting with two estrogen receptors, ERalpha and ERbeta. Drugs that selectively target ERalpha or ERbeta might be safer for conditions that have been traditionally treated with non-selective estrogens. Several synthetic and natural ERbeta-selective compounds have
Iuliia Savchuk et al.
PloS one, 8(8), e71722-e71722 (2013-08-24)
It is well known that estrogens and estrogen-like endocrine disruptors can suppress steroidogenic gene expression, attenuate androgen production and decrease differentiation of adult Leydig cell lineage. However, there is no information about the possible link between the potency of Leydig
Qian Jiang et al.
Purinergic signalling, 13(1), 105-117 (2016-11-07)
Estrogen receptor beta (ERβ) has been shown to play a therapeutic role in inflammatory bowel disease (IBD). However, the mechanism underlying how ERβ exerts therapeutic effects and its relationship with P2X3 receptors (P2X3R) in rats with inflammation is not known.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| PZ0183-25MG | 04061832867670 |
| PZ0183-5MG | 04061832867687 |