PZ0235
PF-04691502
≥98% (HPLC)
别名:
2-Amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one, PF-4691502, PF04691502
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关于此项目
经验公式（希尔记法）:
C22H27N5O4
化学文摘社编号:
分子量:
425.48
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
PF-04691502, ≥98% (HPLC)
form
powder
color
, white to yellow to light brown
SMILES string
CC1=C(C(N([C@H]2CC[C@H](OCCO)CC2)C3=O)=NC(N)=N1)C=C3C4=CN=C(OC)C=C4
InChI
1S/C22H27N5O4/c1-13-17-11-18(14-3-8-19(30-2)24-12-14)21(29)27(20(17)26-22(23)25-13)15-4-6-16(7-5-15)31-10-9-28/h3,8,11-12,15-16,28H,4-7,9-10H2,1-2H3,(H2,23,25,26)/t15-,16-
InChI key
XDLYKKIQACFMJG-WKILWMFISA-N
assay
≥98% (HPLC)
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
room temp
Quality Level
Gene Information
Biochem/physiol Actions
PF-04691502 is a potent dual mTOR/PI3K inhibitor with Ki values of 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ, α, β, γ, and mTOR, respectively, with no significant inhibitory activity at more than 80 other protein kinases, including PI 3-K downstream kinases, and MAPK family members. PF-04691502 showed antitumor activity in several non-small cell lung carcer (NSCLC) xenografts and ovarian cancer cell lines. PF-04691502 is currently in clinical trials.
PF-04691502 is a potent dual mTOR/PI3K inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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