CP-547632 hydrochloride

Name: CP-547632 hydrochloride
Brand: SIGMA

≥98% (HPLC)

别名:

3-[(4-Bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-4-Isothiazolecarboxamide hydrochloride, PF-01371182 hydrochloride

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₂₀H₂₄BrF₂N₅O₃S · HCl

CAS Number:

252003-71-7

分子量:

568.86

MDL编号:

MFCD20268381

UNSPSC代码:

51111800

PubChem化学物质编号:

329823800

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

room temp

SMILES字符串

NC(C1=C(NC(NCCCCN2CCCC2)=O)SN=C1OCC3=C(F)C=C(Br)C=C3F)=O.[H]Cl

InChI

1S/C20H24BrF2N5O3S.ClH/c21-12-9-14(22)13(15(23)10-12)11-31-18-16(17(24)29)19(32-27-18)26-20(30)25-5-1-2-6-28-7-3-4-8-28;/h9-10H,1-8,11H2,(H2,24,29)(H2,25,26,30);1H

InChI key

NNPJZJJMQDXYGN-UHFFFAOYSA-N

生化/生理作用

CP-547632 hydrochloride is a well-tolerated, orally-bioavailable ATP-competitive kinase inhibitor. It is currently in clinical trials for the treatment of human malignancies.

CP-547632 is a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC₅₀ = 11 and 9 nM, respectively). The compound CP-547632 inhibits VEGF and basic FGF-induced angiogenesis in animal models, and inhibits growth of xenograft tumors in mice.