PZ0266
PHA-408
≥98% (HPLC)
别名:
8-（5-氯-2-（4-甲基哌嗪-1-基）异烟酰胺基）-1-（4-氟苯基）-4,5，二氢-1H-苯并[g]吲唑-3-甲酰胺, PHA-00767408, PHA-767408
SMILES string
Fc1ccc(cc1)[n]2nc(c3c2c4c(ccc(c4)NC(=O)c5c(cnc(c5)N6CCN(CC6)C)Cl)CC3)C(=O)N
InChI
1S/C29H27ClFN7O2/c1-36-10-12-37(13-11-36)25-15-23(24(30)16-33-25)29(40)34-19-6-2-17-3-9-21-26(28(32)39)35-38(27(21)22(17)14-19)20-7-4-18(31)5-8-20/h2,4-8,14-16H,3,9-13H2,1H3,(H2,32,39)(H,34,40)
InChI key
ZLEZHGHFWIHCGU-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 5 mg/mL, clear (warmed)
shipped in
dry ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
PHA-408是一种有效的选择性IκB激酶2（IKK-2）抑制剂。PHA-408是一种结合紧密的、ATP竞争性IKK-2抑制剂，对IKK-2的选择性比对IKK-1大350倍（对IKK-2的IC50为10-40 nM，对IKK-1的为14 μM）。 在关节炎的动物模型中，PHA-408被证明可抑制炎症细胞事件，并减少炎症。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Ying Zhong et al.
American journal of physiology. Lung cellular and molecular physiology (2020-05-07)
Cyclic guanosine monophosphate (cGMP) signaling is an important regulator of newborn lung function and development. Although cGMP signaling is decreased in many models of newborn lung injury, the mechanisms are poorly understood. We determined how IL-1β regulates the expression of
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