PZ0277

PF-06281355

Name: PF-06281355
Brand: SIGMA

≥98% (HPLC)

别名:

6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide, PF 6281355, PF-1355

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₅N₃O₄S

化学文摘社编号:

1435467-38-1

分子量:

321.35

NACRES:

NA.77

UNSPSC Code:

51111800

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear (warmed)

storage temp.

room temp

Quality Level

100

Biochem/physiol Actions

PF-06281355 (PF-1355) is an orally available, selective and potent mechanism based inhibitor of the myeloperoxidase (MPO) that reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevated circulating cytokines. PF-06281355 suppresses albuminuria and chronic renal dysfunction in model of anti-Glomerular Basement Membrane (GBM) disease.