PZ0313
PF-04802367
≥98% (HPLC)
别名:
N-(3-(1H-1,2,4-Triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxamide, PF 04802367, PF-367, PF-4802367
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关于此项目
经验公式（希尔记法）:
C16H16ClN5O3
化学文摘社编号:
分子量:
361.78
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
PF-04802367, ≥98% (HPLC)
form
powder
SMILES string
ClC1=CC(C2=C(C(NCCCN3N=CN=C3)=O)N=CO2)=CC=C1OC
InChI
1S/C16H16ClN5O3/c1-24-13-4-3-11(7-12(13)17)15-14(20-10-25-15)16(23)19-5-2-6-22-9-18-8-21-22/h3-4,7-10H,2,5-6H2,1H3,(H,19,23)
InChI key
RQFYFNAGNBUGFC-UHFFFAOYSA-N
assay
≥98% (HPLC)
color
white to beige
solubility
DMSO: 20 mg/mL, clear
shipped in
wet ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
PF-04802367 (PF-367) is a potent and specific ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK-3α/β) with an IC50 value of 2.3 nM and >450-fold selectivity for GSK-3 in a panel of >400 neuroreceptors, enzymes and kinases. GSK-3 dysregulation has been implicated in the pathogenesis of neurological diseases including Alzheimer′s disease.
PF-04802367 is also known as [N-(3-(1H-1,2,4-triazol-1-yl)propyl)-5-(3-chloro-4-methoxyphenyl)oxazole-4-carboxamide) or PF-367. It regulates tau phosphorylation in the brain.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging
Liang S H, et al.
Angewandte Chemie (International Edition in English), 55(33), 9601-9605 (2016)
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