PZ0316
PF-06651600
≥98% (HPLC)
别名:
1-[（2S,5R）-2-甲基-5-（7H-吡咯并[2,3-d]嘧啶-4-基氨基）-1-哌啶基] -2-丙烯-1-酮丙二酸酯, PF 06651600
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选择尺寸
关于此项目
经验公式（希尔记法）:
C15H19N5O · C3H4O4
化学文摘社编号:
分子量:
389.41
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
C[C@@H]1N(C(C=C)=O)C[C@H](NC2=NC=NC3=C2C=CN3)CC1.OC(CC(O)=O)=O
InChI
1S/C15H19N5O.C3H4O4/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15;4-2(5)1-3(6)7/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19);1H2,(H,4,5)(H,6,7)/t10-,11+;/m0./s1
InChI key
QMPMPSGDPRHZCG-VZXYPILPSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 5 mg/mL, clear (warmed)
storage temp.
room temp
Quality Level
Biochem/physiol Actions
PF-06651600 是一种有效的选择性 JAK3 抑制剂。
PF-06651600 特异性靶向 JAK3 的 ATP（腺苷三磷酸）结合结构域（Janus 激酶 3）。JAK3 的功能丧失与严重的联合免疫缺陷综合症有关。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Jak3 deficiency blocks innate lymphoid cell development.
Robinette M L, et al.
Mucosal Immunology, 11(1), 50-50 (2018)
Targeting JAK/STAT signalling in inflammatory skin diseases with small molecule inhibitors.
Welsch K, et al.
European Journal of Immunology, 47(7), 1096-1107 (2017)
Zhenpeng Dai et al.
JCI insight, 6(7) (2021-04-09)
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) are key intracellular mediators in the signal transduction of many cytokines and growth factors. Common γ chain cytokines and interferon-γ that use the JAK/STAT pathway to induce biological responses have been
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