PZ0336
TMI-1
≥98% (HPLC)
别名:
4-[[4-(2-Butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide, TMI 1, WAY-171318
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关于此项目
经验公式（希尔记法）:
C17H22N2O5S2
化学文摘社编号:
分子量:
398.50
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
O=S(N1[C@@H](C(NO)=O)C(C)(C)SCC1)(C2=CC=C(OCC#CC)C=C2)=O
InChI
1S/C17H22N2O5S2/c1-4-5-11-24-13-6-8-14(9-7-13)26(22,23)19-10-12-25-17(2,3)15(19)16(20)18-21/h6-9,15,21H,10-12H2,1-3H3,(H,18,20)/t15-/m0/s1
InChI key
CVZIHNYAZLXRRS-HNNXBMFYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 25 mg/mL, clear
storage temp.
room temp
Quality Level
Biochem/physiol Actions
TMI-1 (WAY-171318) is potent inhibitor of disintegrin metalloenzyme 17 (ADAM17) also known as the tumor necrosis factor-α (TNF-α) converting enzyme (TACE), and matrix metalloprotease (MMP). TMI-1 potently inhibits LPS-induced TNF-α secretion in human primary monocytes, and human whole blood. TMI-1 selectively induces caspase-dependent apoptosis in triple negative (TN) and ERBB2-overexpressing breast tumor cell lines.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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