PZ0344
UK-371,804 HCl
≥98% (HPLC)
别名:
2-(((4-Chloro-1-guanidino-7-isoquinolinyl)sulfonyl)amino)-isobutyric acid hydrochloride, N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-alanine hydrochloride, UK-371804 HCl
InChI
1S/C14H16ClN5O4S.ClH/c1-14(2,12(21)22)20-25(23,24)7-3-4-8-9(5-7)11(19-13(16)17)18-6-10(8)15;/h3-6,20H,1-2H3,(H,21,22)(H4,16,17,18,19);1H
InChI key
IUBFETAFRGVODB-UHFFFAOYSA-N
SMILES string
CC(C)(NS(=O)(C1=CC2=C(C=C1)C(Cl)=CN=C2NC(N)=N)=O)C(O)=O.[H]Cl
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear (warmed)
shipped in
dry ice
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
UK-371,804 is a reversible, substrate-competitive, highly potent (Ki = 10 nM) and selective urokinase-type plasminogen activator (uPA) Inhibitor with excellent selectivity over tPA, plasmin, Factor IXa and Xa. When applied topically, UK-371,80 effectively penetrates into excisional wounds of experimental pigs with no adverse effect on wound closure. UK-371,804 effectively blocks EGR-FMK from binding human uPA even in the presence of tissue proteins.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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