PZ0360
PF-4191834
≥98% (HPLC)
别名:
4-(3-(4-(1-Methyl-1H-pyrazol-5-yl) phenylthio) phenyl)-tetrahydro-2H-pyran-4-carboxamide, PF 4191834, Tetrahydro-4-[3-[[4-(1-methyl-1H-pyrazol-5-yl)phenyl]thio]phenyl]-2H-pyran-4-carboxamide
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关于此项目
经验公式（希尔记法）:
C22H23N3O2S
化学文摘社编号:
分子量:
393.50
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
InChI
1S/C22H23N3O2S/c1-25-20(9-12-24-25)16-5-7-18(8-6-16)28-19-4-2-3-17(15-19)22(21(23)26)10-13-27-14-11-22/h2-9,12,15H,10-11,13-14H2,1H3,(H2,23,26)
SMILES string
NC(C1(CCOCC1)C2=CC=CC(SC3=CC=C(C4=CC=NN4C)C=C3)=C2)=O
InChI key
DVNQWYLVSNPCJZ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
room temp
Quality Level
Biochem/physiol Actions
PF-4191834 is known to reduce the indications of arthritis.
PF-4191834 a selective, non-redox, non-iron chelating competitive inhibitor of 5-lipoxygenase effective in inflammation and pain.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jaime L Masferrer et al.
The Journal of pharmacology and experimental therapeutics, 334(1), 294-301 (2010-04-10)
5-Lipoxygenase (LOX) is an important arachidonic acid-metabolizing enzyme producing leukotrienes and other proinflammatory lipid mediators with potent pathophysiological functions in asthma and other inflammatory diseases. 4-(3-(4-(1-Methyl-1H-pyrazol-5-yl)phenylthio)phenyl)-tetrahydro-2H-pyran-4-carboxamide (PF-4191834) is a novel, selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain. In
Han-Ching Lin et al.
PloS one, 9(9), e107890-e107890 (2014-09-18)
The lipoxygenase isoform of 5-lipoxygenase (5-LOX) is reported to be overexpressed in human rheumatoid arthritis synovial tissue and involved in the progress of inflammatory arthritis. However, the detailed mechanism of how 5-lipoxygenase regulates the inflammatory response in arthritis synovial tissue
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