PZ0407
PF-04957325
≥98% (HPLC)
别名:
3-[[(2R)-4-(2-Thiazolylmethyl)-2-morpholinyl]methyl]-5-(trifluoromethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-7-amine, 3-[[(2R)-4-(thiazol-2-ylmethyl)morpholin-2-yl]methyl]-5-(trifluoromethyl)triazolo[4,5-d]pyrimidin-7-amine
InChI
1S/C14H15F3N8OS/c15-14(16,17)13-20-11(18)10-12(21-13)25(23-22-10)6-8-5-24(2-3-26-8)7-9-19-1-4-27-9/h1,4,8H,2-3,5-7H2,(H2,18,20,21)/t8-/m1/s1
InChI key
VNLPYEMGHGDRRZ-MRVPVSSYSA-N
SMILES string
FC(F)(C1=NC2=C(C(N)=N1)N=NN2C[C@@H]3OCCN(C3)CC4=NC=CS4)F
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
PF-04957325 is a cAMP-competitive, potent and selective phosphodiesterase 8 inhibitor (IC50 = 3.05 nM/PDE8A, 0.44 nM/PDE8B, 1 μM/PDE4D with 12-14 nM cAMP; >1 μM/all other PDEs).
signalword
Danger
hcodes
Hazard Classifications
Self-react. C
存储类别
5.2 - Organic peroxides and self-reacting hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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