Q0875
Quinidine sulfate salt dihydrate
potassium channel blocker
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关于此项目
经验公式（希尔记法）:
C40H48N4O4 · H2O4S · 2H2O
化学文摘社编号:
分子量:
782.94
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-046-3
MDL number:
产品名称
Quinidine sulfate salt dihydrate,
Quality Segment
impurities
≤20% Dihydroquinidine (according to USP specifications., actual content given on label)
mp
212-214 °C (dec.) (lit.)
originator
Bayer
SMILES string
[H]O[H].[H]O[H].OS(O)(=O)=O.[H][C@]1(CN2CCC1C[C@]2([H])[C@@H](O)c3ccnc4ccc(OC)cc34)C=C.[H][C@]5(CN6CCC5C[C@]6([H])[C@@H](O)c7ccnc8ccc(OC)cc78)C=C
InChI
1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1
InChI key
ZHNFLHYOFXQIOW-WFTMRWCJSA-N
General description
Quinidine is an alkaloid present in the bark of the Cinchona tree. It is the D-isomer of quinine, an antimalarial drug.
Application
Quinidine sulfate salt dihydrate has been used as an antiarrhythmic drug to study its effects on phosphorylation and mutations in the cardiac sodium channel Nav1.5.
Biochem/physiol Actions
Class IA antiarrhythmic; potassium channel blocker.
Quinidine shows therapeutic effects against atrial fibrillation and cardiac arrhythmias.
Features and Benefits
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示词
Warning
危险代码
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
闪点 (F)
Not applicable
闪点 (°C)
Not applicable
PPE（个人防护设备）
dust mask type N95 (US), Eyeshields, Gloves