Merck
CN

Q0875

Sigma-Aldrich

Quinidine sulfate salt dihydrate

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经验公式(希尔记法):
C40H48N4O4 · H2O4S · 2H2O
CAS号:
分子量:
782.94
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.77

杂质

≤20% Dihydroquinidine (according to USP specifications., actual content given on label)

mp

212-214 °C (dec.) (lit.)

创始人

Bayer

SMILES string

[H]O[H].[H]O[H].OS(O)(=O)=O.[H][C@]1(CN2CCC1C[C@]2([H])[C@@H](O)c3ccnc4ccc(OC)cc34)C=C.[H][C@]5(CN6CCC5C[C@]6([H])[C@@H](O)c7ccnc8ccc(OC)cc78)C=C

InChI

1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1

InChI key

ZHNFLHYOFXQIOW-WFTMRWCJSA-N

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一般描述

Quinidine is an alkaloid present in the bark of the Cinchona tree. It is the D-isomer of quinine, an antimalarial drug.

应用

Quinidine sulfate salt dihydrate has been used as an antiarrhythmic drug to study its effects on phosphorylation and mutations in the cardiac sodium channel Nav1.5.

生化/生理作用

Quinidine shows therapeutic effects against atrial fibrillation and cardiac arrhythmias.
IA 类抗心律失常药;钾通道阻断剂。

特点和优势

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

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Congenital long QT syndrome type 2 (abnormal hERG potassium channel) patients can develop flat, asymmetric, and notched T waves. Similar observations have been made with a limited number of hERG-blocking drugs. However, it is not known how additional calcium or
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