Q0875
Quinidine sulfate salt dihydrate
potassium channel blocker
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关于此项目
经验公式（希尔记法）:
C40H48N4O4 · H2O4S · 2H2O
化学文摘社编号:
分子量:
782.94
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-046-3
MDL number:
Quality level:
产品名称
Quinidine sulfate salt dihydrate,
InChI key
ZHNFLHYOFXQIOW-WFTMRWCJSA-N
InChI
1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m11.../s1
SMILES string
[H]O[H].[H]O[H].OS(O)(=O)=O.[H][C@]1(CN2CCC1C[C@]2([H])[C@@H](O)c3ccnc4ccc(OC)cc34)C=C.[H][C@]5(CN6CCC5C[C@]6([H])[C@@H](O)c7ccnc8ccc(OC)cc78)C=C
impurities
≤20% Dihydroquinidine (according to USP specifications., actual content given on label)
mp
212-214 °C (dec.) (lit.)
originator
Bayer
Quality Level
General description
Quinidine is an alkaloid present in the bark of the Cinchona tree. It is the D-isomer of quinine, an antimalarial drug.
Application
Quinidine sulfate salt dihydrate has been used as an antiarrhythmic drug to study its effects on phosphorylation and mutations in the cardiac sodium channel Nav1.5.
Biochem/physiol Actions
Class IA antiarrhythmic; potassium channel blocker.
Quinidine shows therapeutic effects against atrial fibrillation and cardiac arrhythmias.
Features and Benefits
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Jose Vicente et al.
Journal of the American Heart Association, 4(4) (2015-04-15)
Congenital long QT syndrome type 2 (abnormal hERG potassium channel) patients can develop flat, asymmetric, and notched T waves. Similar observations have been made with a limited number of hERG-blocking drugs. However, it is not known how additional calcium or
Motoya Suzuki et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(11), 1039-1045 (2014-05-21)
1. This study was aimed to characterize gastrointestinal absorption of digoxin using wild-type (WT) and multidrug resistance protein 1a [mdr1a; P-glycoprotein (P-gp)] knockout (-/-) rats. 2. In WT rats, the area under the plasma concentration-time curve (AUC) of oral digoxin
Yuki Ogawa et al.
European journal of pediatrics, 174(4), 509-518 (2014-09-25)
This study aimed to determine the population pharmacokinetics of doxapram in low-birth-weight (LBW) infants. A total of 92 serum concentration measurements that were obtained from 34 Japanese neonates were analyzed using nonlinear mixed-effect modeling (NONMEM). Estimates generated by NONMEM indicated
Maria Addolorata Saracino et al.
Journal of pharmaceutical and biomedical analysis, 95, 61-67 (2014-03-19)
A rapid and reliable analytical method has been developed to quantify the melatonergic antidepressant agomelatine in three matrices, and namely saliva, plasma and dried blood spots. The method is based on the use of liquid chromatography with fluorimetric detection exploiting
Aleksandra Kasperczyk et al.
Magnesium research, 28(1), 14-22 (2015-05-15)
The present study investigated associations between environmental exposure to magnesium (Mg) and the levels of oxidative stress parameters and selected cytokines, and the antioxidant defense system in the seminal plasma of fertile males. The study population consisted of 57 healthy
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