Q111
(±)-Quinpirole dihydrochloride
powder
别名:
trans-(±)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline dihydrochloride, LY-141,865
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关于此项目
经验公式（希尔记法）:
C13H21N3 · 2HCl
化学文摘社编号:
分子量:
292.25
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
表单
powder
质量水平
颜色
white
溶解性
H2O: 28 mg/mL
储存温度
−20°C
SMILES字符串
Cl.Cl.[H][C@]12CCCN(CCC)[C@]1([H])Cc3cn[nH]c3C2
InChI
1S/C13H21N3.2ClH/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12;;/h9-10,13H,2-8H2,1H3,(H,14,15);2*1H/t10-,13-;;/m1../s1
InChI key
GJIGRGIGKHPYTK-OWVUFADGSA-N
基因信息
human ... DRD2(1813)
相关类别
生化/生理作用
D2-like dopamine receptor agonist that possesses some activity at D3 sites.
法律信息
Manufactured and sold with the permission of Eli Lilly and Company.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Cristina Cariulo et al.
Biochemical and biophysical research communications, 521(3), 549-554 (2019-11-05)
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion of a CAG triplet repeat (encoding for a polyglutamine tract) within the first exon of the huntingtin gene. Expression of the mutant huntingtin (mHTT) protein can result in
D Eilam et al.
European journal of pharmacology, 161(2-3), 151-157 (1989-02-28)
The effects of the D-2 agonist quinpirole on forward progression, and on vertical and lateral movements, were measured for 2 h in rats injected with either saline, 0.03, 0.125, 0.5 or 8 mg/kg of the drug. Results showed that the
S Rosenzweig-Lipson et al.
Pharmacology, biochemistry, and behavior, 51(4), 843-848 (1995-08-01)
The present study investigated whether potassium channel blockade could modify the behavioral effects of the dopamine D2/D3 receptor agonist quinpirole in squirrel monkeys. The duration of immobility and/or unusual postures indicative of catalepsy-associated behavior or the duration of scratching, known
Laura Casares et al.
Redox biology, 37, 101689-101689 (2020-08-31)
Oxidative stress and inflammation in the brain are two key hallmarks of neurodegenerative diseases (NDs) such as Alzheimer's, Parkinson's, Huntington's and multiple sclerosis. The axis NRF2-BACH1 has anti-inflammatory and anti-oxidant properties that could be exploited pharmacologically to obtain neuroprotective effects.
Compounds selective for dopamine receptor subtypes.
Kebabian, et al.
Drug Discovery Today, 2, 333-340 (1997)
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