Q1125
Quinine hydrochloride dihydrate
99-101% (titration), potassium channel blocker
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经验公式（希尔记法）:
C20H24N2O2 · HCl · 2H2O
化学文摘社编号:
分子量:
396.91
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352210
EC Number:
205-001-1
MDL number:
产品名称
Quinine hydrochloride dihydrate,
InChI key
SGVZDMWHXVXUBY-HZQSTTLBSA-N
InChI
1S/C20H24N2O2.ClH.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;1H2/t13-,14-,19-,20+;;/m0../s1
SMILES string
O.Cl.[H][C@]1(C[C@@H]2CC[N@H]1C[C@@H]2C=C)[C@H](O)c3ccnc4ccc(OC)cc34
solubility
H2O: 0.25/5 g/mL, clear, colorless
antibiotic activity spectrum
parasites
mode of action
enzyme | inhibits
Quality Level
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Application
Quinine hydrochloride dihydrate has been used in Drosophila larval behavioral assay. It has also been used in taste preference analysis among rats.
Biochem/physiol Actions
Potassium channel blocker
Quinine is widely used in the treatment of malaria. It possesses erythrocytic and gametocytocidal action against Plasmodium sp. It also serves as an analgesic drug. Upon administration, quinine is present mostly bound to α-1 acid glycoprotein in the body fluids. Quinine has the ability to cross the placenta and the blood brain barrier. It has a half-life of 11-18 hours. Tinnitus, hearing defects, nausea and headache are some of its side effects.
General description
Quinine is derived from the stem of cinchona (quina-quina) tree. It is an alkaloid having various applications in the field of medicine. Quinine is a basic compound with aryl amino alcohol group.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
High-NaCl perception in Drosophila melanogaster
Alves G, et al.
The Journal of Neuroscience, 34(33), 10884-10891 (2014)
The first stereoselective total synthesis of quinine
Stork G, et al.
Journal of the American Chemical Society, 123(14), 3239-3242 (2001)
Preferences of 14 rat strains for 17 taste compounds
Tordoff MG, et al.
Physiology & Behavior, 95(3), 308-332 (2008)
Eleanor K Lutz et al.
The Journal of experimental biology, 223(Pt 7) (2020-03-05)
Mosquitoes spread deadly diseases that impact millions of people every year. Understanding mosquito physiology and behavior is vital for public health and disease prevention. However, many important questions remain unanswered in the field of mosquito neuroethology, particularly in our understanding
Bokyung Song et al.
International journal of molecular sciences, 22(13) (2021-07-03)
Cytokines are important neuroinflammatory modulators in neurodegenerative brain disorders including traumatic brain injury (TBI) and stroke. However, their temporal effects on the physiological properties of microglia and neurons during the recovery period have been unclear. Here, using an ATP-induced cortical
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