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Q2763

醌茜素

Name: 醌茜素
Brand: SIGMA

≥95% (HPLC), powder, plasmodium falciparum casein kinase 2α (PfCK2α) inhibitor

别名:

1,2,5,8-Tetrahydroxy-9,10-anthraquinone, 1,2,5,8-Tetrahydroxyanthraquinone, Alizarin Bordeaux BD, Alizarinbordeaux, Alizarine Bordeaux, Alizarine Bordeaux B, C.I. 58500, C.I. Mordant Violet 26, Khinalizarin, NSC 144046, NSC 4896, PHF 016

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关于此项目

经验公式（希尔记法）:

C₁₄H₈O₆

化学文摘社编号:

81-61-8

分子量:

272.21

UNSPSC Code:

12171500

NACRES:

NA.77

PubChem Substance ID:

329823863

EC Number:

201-366-6

MDL number:

MFCD00001205

Colour Index Number:

58500

Beilstein/REAXYS Number:

1889617

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

醌茜素, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

powder

color

red

mp

≥300 °C

storage temp.

room temp

SMILES string

Oc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O

InChI

1S/C14H8O6/c15-6-3-4-7(16)11-10(6)12(18)5-1-2-8(17)13(19)9(5)14(11)20/h1-4,15-17,19H

InChI key

VBHKTXLEJZIDJF-UHFFFAOYSA-N

说明

Application

Quinalizarin has been used:

as a casein kinase II (CKII) inhibitor to study its effect on CKII-mediated phosphorylation of importin α on subcellular scaling in sperm chromosomes and egg extract
as a CKII inhibitor to study its ability to block parasite multiplication in a [3H]-hypoxanthine incorporation assay
to study its effect on colorectal cancer (CRC) cell cycle arrest, cell apoptosis, and reactive oxygen species (ROS) generation in SW480 and HCT-116 cell lines

Biochem/physiol Actions

Quinalizarin is a potent (IC50 = 110 nM), ATP-competitive, and highly selective (IC50 >1μM against CK1 and 72 other kinases) casein Kinase II (CK2) inhibitor.

Quinalizarin is a potent, ATP-competitive, and highly selective casein Kinase II (CK2) inhibitor.

Studies show that quinalizarin can prevent the in vitro activity of recombinant Plasmodium falciparum casein kinase 2α (PfCK2α) catalytic subunit with an IC50 of 2μM.

pictograms

GHS07,GHS09

signalword

Warning

hcodes

H302,H410

pcodes

P264 - P270 - P273 - P301 + P312 - P391 - P501

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Protein kinase CK2 regulates metal toxicity in neuronal cells.

Mohammad S Zaman et al.

Metallomics : integrated biometal science, 8(1), 82-90 (2015-12-02)

Protein kinase CK2 is a pleiotropic tetrameric enzyme, regulating numerous biological processes from cell proliferation to stress response. This study demonstrates for the first time that CK2 is involved in the regulation of metal uptake and toxicity in neuronal cells.

Involvement of endothelial CK2 in the radiation induced perivascular resistant niche (PVRN) and the induction of radioresistance for non-small cell lung cancer (NSCLC) cells.

Qianwen Li et al.

Biological research, 52(1), 22-22 (2019-04-18)

Tumor microenvironment (TME) plays a vital role in determining the outcomes of radiotherapy. As an important component of TME, vascular endothelial cells are involved in the perivascular resistance niche (PVRN), which is formed by inflammation or cytokine production induced by

Quinalizarin, a specific CK2 inhibitor, reduces cell viability and suppresses migration and accelerates apoptosis in different human lung cancer cell lines.

Y Zhou et al.

Indian journal of cancer, 52 Suppl 2, e119-e124 (2016-01-06)

Protein kinase CK2 is widely expressed in eukaryotic cells, and plays an important role in cell proliferation, migration, apoptosis, etc. The aim of the current study is to explore how Quinalizarin, a specific CK2 inhibitor, affects the cell proliferation, migration

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全球贸易项目编号

货号	GTIN
Q2763-25MG	04061835307937
Q2763-5MG	04061836687892