Q2763
醌茜素
≥95% (HPLC), powder, plasmodium falciparum casein kinase 2α (PfCK2α) inhibitor
别名:
1,2,5,8-Tetrahydroxy-9,10-anthraquinone, 1,2,5,8-Tetrahydroxyanthraquinone, Alizarin Bordeaux BD, Alizarinbordeaux, Alizarine Bordeaux, Alizarine Bordeaux B, C.I. 58500, C.I. Mordant Violet 26, Khinalizarin, NSC 144046, NSC 4896, PHF 016
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关于此项目
经验公式（希尔记法）:
C14H8O6
化学文摘社编号:
分子量:
272.21
UNSPSC Code:
12171500
NACRES:
NA.77
PubChem Substance ID:
EC Number:
201-366-6
MDL number:
Colour Index Number:
58500
Beilstein/REAXYS Number:
1889617
Assay:
≥95% (HPLC)
Form:
powder
产品名称
醌茜素, ≥95% (HPLC)
Quality Segment
assay
≥95% (HPLC)
form
powder
color
red
mp
≥300 °C
storage temp.
room temp
SMILES string
Oc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O
InChI
1S/C14H8O6/c15-6-3-4-7(16)11-10(6)12(18)5-1-2-8(17)13(19)9(5)14(11)20/h1-4,15-17,19H
InChI key
VBHKTXLEJZIDJF-UHFFFAOYSA-N
Application
Quinalizarin has been used:
- as a casein kinase II (CKII) inhibitor to study its effect on CKII-mediated phosphorylation of importin α on subcellular scaling in sperm chromosomes and egg extract
- as a CKII inhibitor to study its ability to block parasite multiplication in a [3H]-hypoxanthine incorporation assay
- to study its effect on colorectal cancer (CRC) cell cycle arrest, cell apoptosis, and reactive oxygen species (ROS) generation in SW480 and HCT-116 cell lines
Biochem/physiol Actions
Studies show that quinalizarin can prevent the in vitro activity of recombinant Plasmodium falciparum casein kinase 2α (PfCK2α) catalytic subunit with an IC50 of 2μM.
Quinalizarin is a potent (IC50 = 110 nM), ATP-competitive, and highly selective (IC50 >1μM against CK1 and 72 other kinases) casein Kinase II (CK2) inhibitor.
Quinalizarin is a potent, ATP-competitive, and highly selective casein Kinase II (CK2) inhibitor.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable