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Q2763

醌茜素

Name: 醌茜素
Brand: SIGMA

≥95% (HPLC), powder, plasmodium falciparum casein kinase 2α (PfCK2α) inhibitor

别名:

1,2,5,8-Tetrahydroxy-9,10-anthraquinone, 1,2,5,8-Tetrahydroxyanthraquinone, Alizarin Bordeaux BD, Alizarinbordeaux, Alizarine Bordeaux, Alizarine Bordeaux B, C.I. 58500, C.I. Mordant Violet 26, Khinalizarin, NSC 144046, NSC 4896, PHF 016

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About This Item

经验公式（希尔记法）:

C₁₄H₈O₆

CAS Number:

81-61-8

分子量:

272.21

颜色索引号:

58500

Beilstein:

1889617

EC 号:

201-366-6

MDL编号:

MFCD00001205

UNSPSC代码:

12171500

PubChem化学物质编号:

329823863

NACRES:

NA.77

Product Name

醌茜素, ≥95% (HPLC)

质量水平

100

方案

≥95% (HPLC)

表单

powder

颜色

red

mp

≥300 °C

储存温度

room temp

SMILES字符串

Oc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O

InChI

1S/C14H8O6/c15-6-3-4-7(16)11-10(6)12(18)5-1-2-8(17)13(19)9(5)14(11)20/h1-4,15-17,19H

InChI key

VBHKTXLEJZIDJF-UHFFFAOYSA-N

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应用

Quinalizarin has been used:

as a casein kinase II (CKII) inhibitor to study its effect on CKII-mediated phosphorylation of importin α on subcellular scaling in sperm chromosomes and egg extract
as a CKII inhibitor to study its ability to block parasite multiplication in a [3H]-hypoxanthine incorporation assay
to study its effect on colorectal cancer (CRC) cell cycle arrest, cell apoptosis, and reactive oxygen species (ROS) generation in SW480 and HCT-116 cell lines

生化/生理作用

Quinalizarin is a potent (IC50 = 110 nM), ATP-competitive, and highly selective (IC50 >1μM against CK1 and 72 other kinases) casein Kinase II (CK2) inhibitor.

Quinalizarin is a potent, ATP-competitive, and highly selective casein Kinase II (CK2) inhibitor.

Studies show that quinalizarin can prevent the in vitro activity of recombinant Plasmodium falciparum casein kinase 2α (PfCK2α) catalytic subunit with an IC50 of 2μM.