Q2763
醌茜素
≥95% (HPLC), powder, plasmodium falciparum casein kinase 2α (PfCK2α) inhibitor
别名:
1,2,5,8-Tetrahydroxy-9,10-anthraquinone, 1,2,5,8-Tetrahydroxyanthraquinone, Alizarin Bordeaux BD, Alizarinbordeaux, Alizarine Bordeaux, Alizarine Bordeaux B, C.I. 58500, C.I. Mordant Violet 26, Khinalizarin, NSC 144046, NSC 4896, PHF 016
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关于此项目
经验公式（希尔记法）:
C14H8O6
化学文摘社编号:
分子量:
272.21
UNSPSC Code:
12171500
NACRES:
NA.77
PubChem Substance ID:
EC Number:
201-366-6
MDL number:
Colour Index Number:
58500
Beilstein/REAXYS Number:
1889617
产品名称
醌茜素, ≥95% (HPLC)
InChI
1S/C14H8O6/c15-6-3-4-7(16)11-10(6)12(18)5-1-2-8(17)13(19)9(5)14(11)20/h1-4,15-17,19H
InChI key
VBHKTXLEJZIDJF-UHFFFAOYSA-N
SMILES string
Oc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O
assay
≥95% (HPLC)
form
powder
color
red
mp
≥300 °C
storage temp.
room temp
Quality Level
Application
Quinalizarin has been used:
- as a casein kinase II (CKII) inhibitor to study its effect on CKII-mediated phosphorylation of importin α on subcellular scaling in sperm chromosomes and egg extract
- as a CKII inhibitor to study its ability to block parasite multiplication in a [3H]-hypoxanthine incorporation assay
- to study its effect on colorectal cancer (CRC) cell cycle arrest, cell apoptosis, and reactive oxygen species (ROS) generation in SW480 and HCT-116 cell lines
Biochem/physiol Actions
Quinalizarin is a potent (IC50 = 110 nM), ATP-competitive, and highly selective (IC50 >1μM against CK1 and 72 other kinases) casein Kinase II (CK2) inhibitor.
Quinalizarin is a potent, ATP-competitive, and highly selective casein Kinase II (CK2) inhibitor.
Studies show that quinalizarin can prevent the in vitro activity of recombinant Plasmodium falciparum casein kinase 2α (PfCK2α) catalytic subunit with an IC50 of 2μM.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Mohammad S Zaman et al.
Metallomics : integrated biometal science, 8(1), 82-90 (2015-12-02)
Protein kinase CK2 is a pleiotropic tetrameric enzyme, regulating numerous biological processes from cell proliferation to stress response. This study demonstrates for the first time that CK2 is involved in the regulation of metal uptake and toxicity in neuronal cells.
Qianwen Li et al.
Biological research, 52(1), 22-22 (2019-04-18)
Tumor microenvironment (TME) plays a vital role in determining the outcomes of radiotherapy. As an important component of TME, vascular endothelial cells are involved in the perivascular resistance niche (PVRN), which is formed by inflammation or cytokine production induced by
Christopher Brownlee et al.
Cell, 176(4), 805-815 (2019-01-15)
Early embryogenesis is accompanied by reductive cell divisions requiring that subcellular structures adapt to a range of cell sizes. The interphase nucleus and mitotic spindle scale with cell size through both physical and biochemical mechanisms, but control systems that coordinately
Bo Yang et al.
Molecular and cellular biochemistry, 436(1-2), 87-97 (2017-07-27)
Non-small cell lung carcinoma (NSCLC), a malignancy of lungs, is very aggressive and usually ends up with a dismal prognosis. Cisplatin (CDDP)-based systemic chemotherapy is the main pharmaceutical approach for treating NSCLC, but its effect is discounted by some hitherto
Ling-Qi Meng et al.
Medical science monitor : international medical journal of experimental and clinical research, 24, 3710-3719 (2018-06-04)
BACKGROUND Quinalizarin (1,2,5,8-tetrahydroxyanthraquinone) exhibits potentially useful anticancer effects by inducing apoptosis in several types of cancer, but its underlying mechanism of action remains unknown. The present study examined the effects of quinalizarin on the induction of cell cycle arrest, apoptosis
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