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关于此项目
经验公式(希尔记法):
C23H30ClN3O · 2HCl
化学文摘社编号:
分子量:
472.88
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352101
EC Number:
200-700-8
MDL number:
Beilstein/REAXYS Number:
4834013
产品名称
喹吖因 二盐酸盐, ≥90%
biological source
synthetic
Quality Level
assay
≥90%
form
powder
mp
257 °C
solubility
H2O: soluble, clear to hazy
originator
Bayer
SMILES string
Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13
InChI
1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
InChI key
UDKVBVICMUEIKS-UHFFFAOYSA-N
Gene Information
human ... MAOA(4128), MAOB(4129)
General description
阿的平是吖啶衍生物,是一种强效抗疟药。
Application
二盐酸奎纳克林已用于:
- 在荧光显微镜下研究其在小鼠肺切片中的摄取和蓄积
- 在间充质干细胞 (MSCs) ATP 囊泡染色中的应用
- 在摄取-释放试验中用于表征血小板致密颗粒功能性
Biochem/physiol Actions
阿的平具有驱虫作用,用于女性绝育。用于治疗系统性红斑狼疮及风湿性疾病。除疟疾外,阿的平对治疗贾第虫和绦虫感染有效。除抑制单胺氧化酶外,还能抑制烟酰胺腺嘌呤二核苷酸磷酸 (NADPH) 氧化酶活性。
非选择性 MAO-A/B 抑制剂。
Preparation Note
储备液在20°C下可稳定保存60h。
Other Notes
本品无有效期或建议的复验期。
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
相关内容
Product Information Sheet
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The Journal of Allergy and Clinical Immunology, 142(2), 630-646 (2018)
Mayur Nimbadas Devare et al.
Aging cell, 19(6), e13151-e13151 (2020-05-26)
Glucose controls the phosphorylation of silent information regulator 2 (Sir2), a NAD+ -dependent protein deacetylase, which regulates the expression of the ATP-dependent proton pump Pma1 and replicative lifespan (RLS) in yeast. TORC1 signaling, which is a central regulator of cell
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| Q3251-100G | 04061836687946 |
| Q3251-25G | 04061836687953 |
