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COO原产地证书/COA分析证书

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Q3625

奎尼丁

Name: 奎尼丁
Brand: SIGMA

sodium channel blocker

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About This Item

经验公式（希尔记法）:

C₂₀H₂₄N₂O₂

CAS Number:

56-54-2

分子量:

324.42

Beilstein:

91866

EC 号:

200-279-0

MDL编号:

MFCD00135581

UNSPSC代码:

12352200

PubChem化学物质编号:

24899331

NACRES:

NA.77

Product Name

奎尼丁, anhydrous

等级

anhydrous

质量水平

200

杂质

≤20% Dihydroquinidine (according to USP specifications., actual content given on label)

mp

168-172 °C (lit.)

创始人

Bayer

SMILES字符串

COc1ccc2nccc([C@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1

InChI

1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1

InChI key

LOUPRKONTZGTKE-LHHVKLHASA-N

基因信息

human ... ABCB1(5243), CYP2D6(1565), CYP3A4(1576), KCNH1(3756), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
mouse ... Abcb1a(18671), Abcb1b(18669)
rat ... Cyp2d1(266684), Cyp2d2(25053), Cyp2d3(24303), Cyp2d4v1(171522)

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应用

Quinidine has been used:

as an inhibitor of cytochrome P450 enzyme isoform CYP2D6
as a potassium (K⁺) channel blocker in microglia
to test its effect on electrophysiological behaviour of human induced pluripotent stem cells (hiPSC) cardiomyocytes

生化/生理作用

IA 类抗心律失常药；钾通道阻断剂。

Quinidine, an isomer of quinine has potential side effects like proarrhythmia on usage. It prolongs cardiac potential and is sodium channel blocker. It is a potential antagonist for α1-adrenoceptors and contributes to hypotension. It inhibits cytochrome P450 2D6 and improves circulation and brain penetration of dementia drug, dextromethorphan. Quinidine-dextromethorphan combination may be useful in treating pseudobulbar affect (PBA).

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.