主要文件

查看所有文档

R0158

RepSox

Name: RepSox
Brand: SIGMA

≥98% (HPLC), solid, TGF-β RI kinase inhibitor

别名:

E-616452; 2-[3-（6-甲基-2-吡啶基）-1H-吡唑-4-基]-1,5-萘啶

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₁₇H₁₃N₅

化学文摘社编号:

446859-33-2

分子量:

287.32

UNSPSC Code:

51111800

PubChem Substance ID:

329823975

NACRES:

NA.77

MDL number:

MFCD09037561

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

产品名称

RepSox, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >20 mg/mL

storage temp.

2-8°C

SMILES string

Cc1cccc(n1)-c2n[nH]cc2-c3ccc4ncccc4n3

InChI

1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)

InChI key

LBPKYPYHDKKRFS-UHFFFAOYSA-N

正在寻找类似产品? 访问产品对比指南

Application

RepSox已被用于转化生长因子β激酶1型受体(ALK5)的抑制剂。此外，还可用于基本培养基成分，以培养人类多能干细胞。

Biochem/physiol Actions

RepSox通过抑制SMAD族成员3 (Smad3)和c-Jun n -端激酶(JNK)途径/激活蛋白质1 (AP-1)途径，抑制破骨细胞分化、骨组织吸收和卵巢切除术(OVX)诱导的骨质疏松症(OP)。

RepSox 抑制 TGF-β 受体信号。

RepSox 抑制 TGF-β 受体信号。逆转录病毒转导 Sox2、Oct4 和 Klf4 基因导致体细胞直接重编程为诱导多能干细胞 (iPSC)。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

An Integrated Genomic Approach Identifies HOXC8 as an Upstream Regulator in Ovarian Endometrioma.

Yumiko Mihara et al.

The Journal of clinical endocrinology and metabolism, 105(12) (2020-09-03)

To identify the upstream regulators (URs) involved in the onset and pathogenesis of ovarian endometrioma. Recently, a method called Significance-based Modules Integrating the Transcriptome and Epigenome (SMITE) that uses transcriptome data in combination with publicly available data for identifying URs

Phosphorylation of NEUROG3 links endocrine differentiation to the cell cycle in pancreatic progenitors

Krentz N, et al.

Developmental Cell, 41(2), 129-142 (2017)

Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins.

Alice C Newman et al.

Nature communications, 8(1), 1537-1537 (2017-11-18)

Macroautophagy can regulate cell signalling and tumorigenesis via elusive molecular mechanisms. We establish a RAS mutant cancer cell model where the autophagy gene ATG5 is dispensable in A549 cells in vitro, yet promotes tumorigenesis in mice. ATG5 represses transcriptional activation

Establishment of a normal-derived estrogen receptor-positive cell line comparable to the prevailing human breast cancer subtype

Hopkinson B, et al.

Testing, 8(6), 10580-10580 (2017)

Small molecule inhibitor RepSox prevented ovariectomy-induced osteoporosis by suppressing osteoclast differentiation and bone resorption

Mei L, et al.

Journal of Cellular Physiology, 233(12) (2018)

查看所有相关文献

全球贸易项目编号

货号	GTIN
R0158-25MG	04061833221082
R0158-5MG	04061836693749

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持