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Merck
CN

R0404

雷米普利

synthetic (organic), ≥98% (HPLC), Angiotensin converting enzyme (ACE) inhibitor., powder

别名:

Tritace, [2S,3aS,6aS]-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]octahydrocyclopenta[b]pyrrole-2-carboxylic acid

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关于此项目

经验公式（希尔记法）:
C23H32N2O5
化学文摘社编号:
87333-19-5
分子量:
416.51
UNSPSC Code:
12352200
PubChem Substance ID:
24724586
NACRES:
NA.77
MDL number:
MFCD00865775
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

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产品名称

雷米普利, ≥98% (HPLC)

SMILES string

O=C(N1[C@](CCC2)([H])[C@]2([H])C[C@H]1C(O)=O)[C@H](C)N[C@H](C(OCC)=O)CCC3=CC=CC=C3

InChI key

HDACQVRGBOVJII-JBDAPHQKSA-N

InChI

1S/C23H32N2O5/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)/t15-,17-,18-,19-,20-/m0/s1

biological source

synthetic (organic)

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: ~18 mg/mL

originator

Sanofi Aventis

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... ACE(1636)

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相关类别

Biochem/physiol Actions

Angiotensin converting enzyme (ACE) inhibitor.

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000454439
0000454439
0000385031
0000382358
0000373028

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Guillaume Pare et al.
Pharmacogenetics and genomics, 23(9), 470-478 (2013-07-11)
The objective of this study was to identify genetic variants associated with angiotensin-converting enzyme (ACE) inhibitor-associated angioedema. We carried out a genome-wide association study in 175 individuals with ACE inhibitor-associated angioedema and 489 ACE inhibitor-exposed controls from Nashville (Tennessee) and
Daniela Dunkler et al.
JAMA internal medicine, 173(18), 1682-1692 (2013-08-14)
Type 2 diabetes mellitus and associated chronic kidney disease (CKD) have become major public health problems. Little is known about the influence of diet on the incidence or progression of CKD among individuals with type 2 diabetes. To examine the
Carla Zoja et al.
American journal of physiology. Renal physiology, 304(6), F808-F819 (2012-11-09)
Bardoxolone methyl is an antioxidant inflammation modulator acting through induction of Keap1-Nrf2 pathway. Results from a recent phase IIb clinical trial reported that bardoxolone methyl was associated with improvement in the estimated glomerular filtration rate in patients with advanced chronic
G Castoldi et al.
American journal of nephrology, 37(1), 65-73 (2013-01-19)
Diabetic nephropathy is the main cause of end-stage renal disease. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP), a physiological tetrapeptide hydrolyzed by the angiotensin-converting enzyme (ACE), has antifibrotic effects in the cardiovascular system and in the kidney in experimental models of hypertension, heart failure and
Joshua I Barzilay et al.
Clinical journal of the American Society of Nephrology : CJASN, 8(2), 233-240 (2012-11-28)
The microvascular circulation plays an important role in bone health. This study examines whether albuminuria, a marker of renal microvascular disease, is associated with incident hip and pelvic fractures. This study reanalyzed data from the Ongoing Telmisartan Alone and in
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