R0658
RN-1734
≥98% (HPLC)
别名:
2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide
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关于此项目
经验公式（希尔记法）:
C14H22Cl2N2O2S
化学文摘社编号:
分子量:
353.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
RN-1734, ≥98% (HPLC)
InChI key
IHYZMEAZAIFMTN-UHFFFAOYSA-N
SMILES string
ClC1=C(S(N(C(C)C)CCNC(C)C)(=O)=O)C=CC(Cl)=C1
InChI
1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3
assay
≥98% (HPLC)
form
powder
color
white to off-white
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
Quality Level
Application
RN-1734 has been used as a transient receptor potential vanilloid 4 (TRPV4) blocker to study its effects on differentiation of a corneal epithelial cell model, RCE1(5T5) cells.
Biochem/physiol Actions
RN-1734 is a selective TRPV4 antagonist.
存储类别
11 - Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
TRPV4 regulates tight junctions and affects differentiation in a cell culture model of the corneal epithelium
Martinez R, et al.
Journal of Cellular Physiology, 232(7), 1794-1807 (2017)
Jacqueline Martínez-Rendón et al.
Journal of cellular physiology, 232(7), 1794-1807 (2016-11-22)
TRPV4 (transient receptor potential vanilloid 4) is a cation channel activated by hypotonicity, moderate heat, or shear stress. We describe the expression of TRPV4 during the differentiation of a corneal epithelial cell model, RCE1(5T5) cells. TRPV4 is a late differentiation
Hitesh Soni et al.
American journal of physiology. Renal physiology, 313(5), F1136-F1148 (2017-08-05)
Myogenic response, a phenomenon in which resistance size arteries and arterioles swiftly constrict or dilate in response to an acute elevation or reduction, respectively, in intravascular pressure is a key component of renal autoregulation mechanisms. Although it is well established
Vittorio Abbonante et al.
Haematologica, 102(7), 1150-1160 (2017-04-16)
Megakaryocytes (MK) in the bone marrow (BM) are immersed in a network of extracellular matrix components that regulates platelet release into the circulation. Combining biological and bioengineering approaches, we found that the activation of transient receptor potential cation channel subfamily
Silvia Ghirga et al.
Journal of the Optical Society of America. A, Optics, image science, and vision, 37(4), 643-652 (2020-05-14)
It has been recently demonstrated that the exposure of naive neuronal cells to light-at the basis of optogenetic techniques and calcium imaging measurements-may alter neuronal firing. Indeed, understanding the effect of light on nongenetically modified neurons is crucial for a
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