R137
Ro 31-0432
solid
别名:
3-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methylindol-3-yl)maleimide hydrochloride, 3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride, Bisindoylmaleimide XI
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关于此项目
经验公式（希尔记法）:
C28H28N4O2 · HCl
化学文摘社编号:
分子量:
489.01
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (TLC)
Form:
solid
Storage condition:
protect from light
biological source
synthetic (organic)
assay
≥98% (TLC)
form
solid
storage condition
protect from light
color
orange
solubility
DMSO: 5 mg/mL, H2O: insoluble
storage temp.
−20°C
SMILES string
Cl.CN(C)CC1CCn2c(C1)c(C3=C(C(=O)NC3=O)c4cn(C)c5ccccc45)c6ccccc26
InChI
1S/C28H28N4O2.ClH/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21;/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34);1H
InChI key
HSPRASOZRZDELU-UHFFFAOYSA-N
Biochem/physiol Actions
Protein kinase C (PKC) inhibitor; membrane-derived PKC inhibitor.
Features and Benefits
This compound is featured on the GRKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Photosensitive
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
S E Wilkinson et al.
The Biochemical journal, 294 ( Pt 2), 335-337 (1993-09-01)
The protein kinase C (PKC) family of isoenzymes is believed to mediate a wide range of signal-transduction pathways in many different cell types. A series of bisindolylmaleimides have been evaluated as inhibitors of members of the conventional PKC family (PKCs-alpha
Soo Jung Lee et al.
International journal of molecular sciences, 20(24) (2019-12-11)
MicroRNAs (miRNAs) can be used to target a variety of human malignancy by targeting their oncogenes or tumor suppressor genes. The developmental endothelial locus-1 (Del-1) might be under miRNA regulation. This study investigated microRNA-137 (miR-137) function and Del-1 expression in
D Gozal et al.
Journal of applied physiology (Bethesda, Md. : 1985), 84(2), 641-648 (1998-02-26)
Although protein kinase C (PKC) is an essential component of multiple neurally mediated events, its role in respiratory control remains undefined. The ventilatory effects of a systemically active PKC inhibitor (Ro-32-0432; 100 mg/kg i.p.) were assessed by whole body plethysmography
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| R137-1MG | 04061826132272 |
| R137-5MG | 04061832449630 |